Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis
Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis
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DOI：
10.1111/j.1468-3083.2010.03934.x
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发表时间：
2011-10-01
影响因子：
9.2
通讯作者：
Dreno, B.
中科院分区：
文献类型：
--
作者：
Brocard, A.;Dreno, B.
背景锌是多种金属酶的辅因子，在细胞增殖和免疫调节中起着重要作用。它已被不同的数据表明，它可以发挥至关重要的作用，不仅在适应性免疫的调节，而且在先天免疫，其中发挥了至关重要的作用，在skin.Objectives在这篇文章中，我们提出了一个综述的文献中发表的信息，锌和皮肤的先天免疫。结果/结论锌盐对不同靶点皮肤天然免疫的特异性活性可以解释为什么锌更特异地参与炎症起特别重要作用的皮肤病，如炎性痤疮，肠病性肢端皮炎、化脓性汗腺炎、脱发性毛囊炎。
Background Zinc is a cofactor of many metalloenzymes explaining that it plays a crucial role in cell proliferation and also in the regulation of immune system. It has been shown by different data that it could play a crucial role not only in the regulation of adaptative immunity but also in innate immunity which plays a crucial role in skin.Objectives In this article, we proposed an overview of published information in the literature, on zinc and cutaneous innate immunity.Methods At the basic level, we gave a synthesis of data related to zinc's cutaneous targets in innate immunity, and then at clinical level selected studies on cutaneous disorders where zinc could be a therapeutic approach and discussed the targets of zinc in these pathologies.Results/Conclusion The specific activity of zinc salts on the innate immunity of the skin with different targets can explain why zinc is more specifically involved in cutaneous affection in which inflammation plays a particular important role, such as inflammatory acne, acrodermatitis enteropathica, hidradenitis suppurativa, folliculitis decalvans.