L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
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DOI：
10.1016/s0028-3932(03)00117-9
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Cools, R;Barker, RA;Robbins, TW
在当前的研究中，我们通过检查帕金森病（PD）患者停用多巴胺能药物的影响来研究多巴胺在注意力和社会情绪功能中的作用。服用药物的患者在决策任务中表现出异常的投注策略，反映了冲动行为和/或延迟厌恶，而同样服用药物的患者在两个任务之间切换时表现出异常增加的切换成本，反映了注意力的不灵活性。因此，这些数据重复并扩展了先前的发现，即多巴胺能药物改善或损害认知表现取决于任务的性质和底层皮质纹状体回路中多巴胺功能的基础水平。2003爱思唯尔科学有限公司版权所有。
In the current study we investigated the role of dopamine in attentional and socio-emotional functioning by examining effects of withdrawing dopaminergic medication in patients with Parkinson's disease (PD). Patients 'on' medication exhibited abnormal betting strategies on a task of decision-making, reflecting impulsive behaviour and/or delay aversion, whilst the same patients 'off' medication exhibited abnormally increased switch costs when switching between two tasks, reflecting attentional inflexibility. Hence, these data replicate and extend previous findings that dopaminergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of dopamine function in underlying cortico-striatal circuitry. (C) 2003 Elsevier Science Ltd. All rights reserved.