The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).
The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).
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药房补充措施在评估围产期获得性 HIV (PHIV) 青少年的依从性和预测 HIV 疾病标志物方面的作用。
DOI：
10.1007/s10461-019-02468-x
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发表时间：
2019
影响因子：
4.4
通讯作者：
MemoryandExecutiveFunctioningStudyofthePediatricHIV/AIDSCohortStudy
中科院分区：
文献类型：
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作者：
Yildirim,Cenk;Garvie,PatriciaA;Chernoff,Miriam;Wilkins,MeganL;Patton,EDoyle;Williams,PaigeL;Nichols,SharonL;MemoryandExecutiveFunctioningStudyofthePediatricHIV/AIDSCohortStudy
抗逆转录病毒（ARV）的坚持是至关重要的，在监测疾病的反应，在青年与围产期获得性艾滋病毒（PHIV）。我们使用PHACS记忆子研究中PHIV青年的药房再填充（PR）信息来计算2个月、4个月和6个月的药物可用性。将PR（依从性的代表）与自我报告的7天依从性进行比较，以预测抑制的病毒载量（SVL < 400拷贝/mL）和较高的CD4%（≥ 25%）。在159名PHIV青年中，79%的人坚持7天的回忆，62，55和48%的PR超过2，4和6个月，分别。7天回忆和PR依从性之间的一致性较弱（Kappa = 0.09-0.25）。在调整后的逻辑回归模型中，7天召回（OR 2.78，95%CI 1.08，7.15）和所有PR覆盖期（6个月：OR 3.24，95%CI 1.22，8.65）的依从性与SVL相关。观察到与较高的CD4%类似的相关性。PR指标可预测研究保留率。研究结果表明，PR依从性措施可能发挥独立作用。
Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.