The effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury.
The effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury.
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阿格列汀对大鼠颈动脉球囊损伤后内膜增生的影响
DOI：
10.3892/mmr.2017.7667
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发表时间：
2017-12
影响因子：
3.4
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Li Q;Wu X;Liu Y;Zhang M;Bai X;Chen C
本研究评价了Anagliptin对SD大鼠颈动脉损伤后内膜增生的影响。SD大鼠体重280~300g，用2FFogarty球囊取栓术。将大鼠分为生理盐水损伤组和Anagliptin(10 mg/kg/d)治疗组。在左侧颈动脉造成血管损伤，然后在第28天评估新生内膜的形成。取左右颈总动脉进行组织学评价，用双抗体夹心法检测血浆中高血糖素样多肽1受体1、基质细胞衍生因子1α、白介素6、白介素1β和肿瘤坏死因子α的活性。Anagliptin治疗减少球囊损伤诱导的新生内膜形成，与损伤组相比(P<；0.01)。体重和食物消耗量在接受Anagliptin治疗后没有改变。Anagliptin导致血清活性GLP-1浓度较损伤组升高。另外，Anagliptin可显著降低血清sdf-1α水平(P<；0.001)。Anagliptin可改善血清IL-6、IL-1β和肿瘤坏死因子-α活性(P<；0.01)。本研究的结果表明，Anagliptin通过抑制炎症细胞因子和趋化因子来抑制球囊损伤后新生内膜的形成，二肽基肽酶4抑制剂的治疗可能有助于未来的临床前研究，并有可能抑制经皮冠状动脉介入治疗后血栓的形成。
The present study evaluated the effect of anagliptin on intimal hyperplasia following carotid artery injury in Sprague-Dawley rats. Sprague-Dawley rats weighing 280–300 g were injured using a 2F Fogarty balloon embolectomy catheter. The rats were divided into injury-(saline) and anagliptin-(10 mg/kg/day) treated groups. vascular injuries were induced in the left carotid artery, followed by evaluation of neointima formation at 28 days. The right and left carotid arteries were harvested and evaluated with histological evaluation, and the plasma activity of glucagon-like peptide 1 receptor (GLP-1), stromal cell-derived factor (SDF)-1α, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α were detected by ELISA analysis. Treatment with anagliptin decreased balloon injury-induced neointima formation, compared with the injury group (P<0.01). Body weight and food consumption did not alter following treatment with anagliptin. Anagliptin caused an increase in the serum active GLP-1 concentration, compared with the injury group. In addition, serum SDF-1α was significantly decreased by treatment with anagliptin (P<0.001). Anagliptin altered the serum activity of IL-6, IL-1β and TNF-α (P<0.01). The results of the present study demonstrated that anagliptin appeared to attenuate neointimal formation by inhibiting inflammatory cytokines and chemokines following balloon injury, and that treatment with a dipeptidyl peptidase 4 inhibitor may be useful for future preclinical studies and potentially for the inhibition of thrombosis formation following percutaneous coronary intervention.
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影响因子：
--
作者：
Paneghetti L;Ng YS
通讯作者：
Ng YS
影响因子：
24
作者：
McDonald RA;Halliday CA;Miller AM;Diver LA;Dakin RS;Montgomery J;McBride MW;Kennedy S;McClure JD;Robertson KE;Douglas G;Channon KM;Oldroyd KG;Baker AH
通讯作者：
Baker AH
DOI：
10.1161/circinterventions.116.003698
发表时间：
2016-08-01
影响因子：
5.6
作者：
Cassese, Salvatore;Hoppmann, Petra;Kastrati, Adnan
通讯作者：
Kastrati, Adnan
影响因子：
20.1
作者：
Abi-Younes, S;Sauty, A;Luster, AD
通讯作者：
Luster, AD
影响因子：
9.8
作者：
Hirano, Tsutomu;Yamashita, Satoko;Goto, Moritaka
通讯作者：
Goto, Moritaka