Sex difference in cellular retinol- and retinoic acid-binding proteins in human colon adenocarcinomas.
Sex difference in cellular retinol- and retinoic acid-binding proteins in human colon adenocarcinomas.
复制标题
人结肠腺癌中细胞视黄醇和视黄酸结合蛋白的性别差异。
DOI：
10.1016/0304-3835(80)90099-3
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发表时间：
1980
期刊：
影响因子：
9.7
通讯作者：
S. Romney
中科院分区：
文献类型：
--
作者：
P. Palan;C. Duttagupta;S. Romney
用蔗糖梯度法检测同一患者的结肠腺癌和癌旁正常结肠组织中视黄醇(CRBP)和视黄酸(CRABP)细胞结合蛋白的存在和含量。在男性患者中，结肠癌组织中CRBP和CRABP的平均浓度均显著高于邻近正常结肠组织。相比之下，在女性结肠癌中，这两种结合蛋白的平均水平比邻近正常结肠的浓度降低了大约2倍。这些发现揭示了人类结肠恶性肿瘤中视黄醇和视黄酸结合蛋白的意外性别差异。
Human colon adenocarcinomas and adjacent non-cancerous, normal colon from the same patient were assayed for the presence and amounts of cellular binding proteins for retinol (CRBP) and retinoic acid (CRABP) by sucrose gradient analysis. In male patients, the mean concentrations of both CRBP and CRABP in the colon cancers were statistically significantly higher than in the adjacent normal colon. By contrast, in female colon cancers, the mean levels for both binding proteins were reduced approximately 2-fold, compared to the concentrations in the adjacent normal colon. These findings reveal an unexpected sex difference in the binding proteins for retinol and retinoic acid in human colon malignancies.