Challenge to Unity: Relationship Between Hemispheric Asymmetry of the Default Mode Network and Mind Wandering
Challenge to Unity: Relationship Between Hemispheric Asymmetry of the Default Mode Network and Mind Wandering
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DOI：
10.1093/cercor/bhy086
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发表时间：
2019-05-01
期刊：
影响因子：
3.7
通讯作者：
Nomura, Michio
中科院分区：
文献类型：
--
作者：
Kajimura, Shogo;Kochiyama, Takanori;Nomura, Michio
默认模式网络（DMN）被认为是一个统一的核心脑功能，用于产生主观心理体验，如走神。我们提出了一个新的认知框架，从半球不对称的角度来理解DMN的统一性。使用经颅直流电刺激（tDCS），有效的连接估计和机器学习，我们表明，双侧角回（AG），这是DMN的核心区域，表现出异质性的内在网络组织和思维游荡的调节。固有的异质性之间存在的权利和左AG不仅有效的连接，但也走神的调节;右AG是与走神减少，而左AG是与走神的产生。进一步支持这一观察结果，我们发现只有右AG的阳极tDCS诱导了有效连接和区域振幅的机器学习可检测变化，这可能与减少思维漫游有关。我们的研究结果强调了半球不对称的重要性，以进一步了解DMN的功能，并有助于新兴的思维游荡的神经模型，这是必要的，以了解人类心灵的本质。
The default mode network (DMN) is considered a unified core brain function for generating subjective mental experiences, such as mind wandering. We propose a novel cognitive framework for understanding the unity of the DMN from the perspective of hemispheric asymmetry. Using transcranial direct current stimulation (tDCS), effective connectivity estimation, and machine learning, we show that the bilateral angular gyri (AG), which are core regions of the DMN, exhibit heterogeneity in both inherent network organization and mind wandering regulation. Inherent heterogeneities are present between the right and left AG regarding not only effective connectivity, but also mind wandering regulation; the right AG is related to mind-wandering reduction, whereas the left AG is related to mind-wandering generation. Further supporting this observation, we found that only anodal tDCS of the right AG induced machine learning-detectable changes in effective connectivity and regional amplitude, which could possibly be linked to reduced mind wandering. Our findings highlight the importance of hemispheric asymmetry to further understand the function of the DMN and contribute to the emerging neural model of mind wandering, which is necessary to understand the nature of the human mind.