Reverse water-in-fluorocarbon emulsions and microemulsions obtained with a fluorinated surfactant
Reverse water-in-fluorocarbon emulsions and microemulsions obtained with a fluorinated surfactant
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DOI：
10.1016/j.colsurfa.2004.06.003
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发表时间：
2004-09-06
影响因子：
5.2
通讯作者：
Krafft, MP
中科院分区：
文献类型：
--
作者：
Courrier, HA;Vandamme, TF;Krafft, MP
纯碳氟化合物（fc）正在被研究用于药物和基因的肺部输送，这引发了人们对将碳氟化合物水乳液作为亲水生物活性物质输送到肺部的系统的兴趣。在本文中，我们研究了一系列具有二morpholin磷酸盐极性头基的全氟烷基化两亲化合物CnF2n+1(CH2)(m)OP(O)[N(CH2CH2)O](2) （FnHmDMP, N = 4,6,8,10和m = 2,5,11）对氟碳化合物中水的乳化能力。发现F8H11DMP可以获得稳定的fc水乳液和微乳液。对于给定的配方（5% （v/v）水，95% （v/v）全氟辛基溴），F8H11DMP浓度为1.5%至5% (w/v)，可获得稳定的，窄分散的微型乳液（25℃条件下1年后平均直径：120-150nm）。分子扩散（奥斯特瓦尔德成熟）被确定为这些微乳中液滴生长的主要机制。当F8H11DMP浓度大于5% （w/v）时，可制得直径为12 nm的fc水微乳液。(C) 2004 Elsevier B.V.版权所有
Neat fluorocarbons (FCs) are being investigated for pulmonary delivery of drugs and genes, triggering interest on reverse water-in-fluorocarbon emulsions as delivery systems for hydrophilic bioactive materials to the lung. In this paper we examine the ability of a series of perfluoroalkylated amphiphiles with a dimorpholinophosphate polar head group, CnF2n+1(CH2)(m)OP(O)[N(CH2CH2)O](2) (FnHmDMP, n = 4,6,8,10 and m = 2,5, 11) to emulsify water in fluorocarbons. F8H11DMP was found to allow the obtaining of both stable water-in-FC emulsions and of microemulsions. For a given formulation (5% (v/v) water, 95% (v/v) perfluorooctyl bromide) stable, narrowly dispersed miniemulsions (mean diameter: 120-150nm after 1 year at 25degreesC) were obtained with F8H11DMP concentrations ranging from 1.5% to 5% (w/v). Molecular diffusion (Ostwald ripening) was determined to be the predominant mechanism of droplet growth in these miniemulsions. For F8H11DMP concentrations higher than 5% (w/v), water-in-FC microemulsions, 12 nm in diameter, were obtained. (C) 2004 Elsevier B.V. All rights reserved.