Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.
Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.
复制标题
豚鼠（一种对生长激素无反应的哺乳动物）生长激素和受体的分子进化。
DOI：
10.1016/s0378-1119(00)00053-6
复制
发表时间：
2000
期刊：
影响因子：
3.5
通讯作者：
Li,WH
中科院分区：
文献类型：
--
作者：
Adkins,RM;Vandeberg,J;Li,WH
豚鼠的生长对内源性或外源性生长激素完全无反应，尽管豚鼠产生正常至高水平的生长激素和受体。在灵长类动物和偶蹄类动物中，生长激素表现出加速的进化速度，似乎与功能的变化有关。令人惊讶的是，豚鼠生长激素和受体表现出类似于在其他哺乳动物中看到的缓慢的进化速率，这意味着这两种蛋白质在豚鼠中的功能保守，在其他哺乳动物中，或任何损失或放松的功能约束是最近。然而，豚鼠生长激素和受体都在已知具有功能意义的位点处表现出单个氨基酸置换。然而，目前还不清楚是否豚鼠生长激素-生长激素受体轴的异常性质是由于这些替代或是否是由于在后受体信号传导的缺陷。
Growth in the guinea-pig is completely unresponsive to endogenous or exogenous growth hormone, despite the fact that the guinea-pig produces normal to high levels of growth hormone and receptor. In primates and artiodactyls, growth hormone exhibits accelerated rates of evolution that appear to be correlated with changes in function. Surprisingly, both guinea-pig growth hormone and receptor exhibit slow rates of evolution similar to those seen in other mammals, implying that both proteins are as functionally conserved in the guinea-pig as in other mammals or that any loss or relaxation of functional constraint was very recent. However, the guinea-pig growth hormone and receptor both exhibit a single amino acid replacement at a site known to have functional significance. Nevertheless, it is unclear whether the aberrant nature of the guinea-pig growth hormone-growth hormone receptor axis is due to these replacements or whether it is due to a defect in post-receptor signalling.