Birth weight and longitudinal growth in infants born below 32 weeks' gestation: a UK population study.
Birth weight and longitudinal growth in infants born below 32 weeks' gestation: a UK population study.
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DOI：
10.1136/archdischild-2012-303536
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发表时间：
2014-01
期刊：
影响因子：
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通讯作者：
Neonatal Data Analysis Unit and the Preterm Growth Investigator Group
中科院分区：
文献类型：
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作者：
Cole TJ;Statnikov Y;Santhakumaran S;Pan H;Modi N;Neonatal Data Analysis Unit and the Preterm Growth Investigator Group
使用常规采集的电子临床数据，描述同期妊娠<32周出生婴儿人群的出生体重和出生后体重增加。2006年至2011年匿名纵向体重数据。英国国家卫生服务新生儿单位。使用LMS方法构建出生体重百分位数，使用SITAR（平移和旋转叠加）生长曲线分析，将妊娠至出院期间每周的纵向体重增量总结为平均生长曲线。从40个新生儿单位获得了5009名孕22-31周出生的婴儿的103194个体重数据。 出生时，女孩的体重比男孩轻6.6%（SE 0.4%）（p<0.0001）。对于妊娠31周出生的婴儿，出生后体重平均下降258克，出生后第8天达到最低点。 3周后，体重增加率增加至最大值28.4 g/d或16.0 g/kg/d。 相反，对于妊娠22至28周的婴儿，出生后平均体重没有减轻。 在所有妊娠期，婴儿倾向于在至少2周内向下跨越体重百分位数。 在极早产儿中，平均体重向下穿过百分位数至少两个百分位数通道宽度。出生后体重减轻通常在29周前出生的人中不存在，但在出生后明显。 婴儿出生时的目标百分位数是潜在有害的，因为它需要快速增加体重，只有在体重增加稳定后才应该这样做。电子数据的使用反映了现代医疗管理。
To describe birth weight and postnatal weight gain in a contemporaneous population of babies born <32 weeks’ gestation, using routinely captured electronic clinical data. Anonymised longitudinal weight data from 2006 to 2011. National Health Service neonatal units in England. Birth weight centiles were constructed using the LMS method, and longitudinal weight gain was summarised as mean growth curves for each week of gestation until discharge, using SITAR (Superimposition by Translation and Rotation) growth curve analysis. Data on 103 194 weights of 5009 babies born from 22–31 weeks’ gestation were received from 40 neonatal units. At birth, girls weighed 6.6% (SE 0.4%) less than boys (p<0.0001). For babies born at 31 weeks’ gestation, weight fell after birth by an average of 258 g, with the nadir on the 8th postnatal day. The rate of weight gain then increased to a maximum of 28.4 g/d or 16.0 g/kg/d after 3 weeks. Conversely for babies of 22 to 28 weeks’ gestation, there was on average no weight loss after birth. At all gestations, babies tended to cross weight centiles downwards for at least 2 weeks. In very preterm infants, mean weight crosses centiles downwards by at least two centile channel widths. Postnatal weight loss is generally absent in those born before 29 weeks, but marked in those born later. Assigning an infant's target centile at birth is potentially harmful as it requires rapid weight gain and should only be done once weight gain has stabilised. The use of electronic data reflects contemporary medical management.