Expression of HBD-2 in saliva of oral diseases
Expression of HBD-2 in saliva of oral diseases
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口腔疾病唾液中HBD-2的表达
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发表时间：
2008
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目的：人β防御素因其抗菌活性在粘膜免疫系统中发挥重要作用。本研究旨在检测口腔扁平苔藓（OLP）、口腔白斑（OLK）和口腔念珠菌病患者非刺激性唾液（WUS）中人β防御素2的含量。方法：收集40例口腔扁平苔藓（OLP）、口腔扁平苔藓（OLK）、口腔念珠菌病患者的WUS标本，男18例，女22例，年龄20~55岁。对照组20例，平均年龄25岁。Western Blotting检测唾液β防御素2。结果：HBD-2在正常对照组中阳性率为12/20，所有患者HBD-2阳性率均高于正常对照组。结论：HBD-2在口腔疾病中的表达变化反映了口腔疾病的感染程度，提示β防御素可能与口腔癌前病变有关。
Objective: Human beta defensins play a important role for their antimicrobial activity in mucosa immune system. This study aims to detect human beta defensin 2 in whole unstimulated saliva(WUS) of oral lichen planus(OLP), oral leukoplakia(OLK)and oral candidiasis. Method:The WUS samples were collected in a group of 40 patients (18 men, 22 women) with 20 cases of OLP,10 cases of OLK,10 cases of oral candidiasis,age range 20～55 years. Control group consisted of 20 healhy controls, mean age 25 years. Saliva beta defensin 2 was detected by Western Blotting. Result:HBD-2 was detected in 12/20 controls and all patients which was higher than that in controls. Conclusion:These results show that the change of HBD-2 in oral diseases reflects the infection degree,but also indicate that there maybe relationship between human beta defensins and pre-malignant diseases.