Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study.
Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study.
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在一项基于人群的研究中，膳食总抗氧化能力与前列腺癌的侵袭性呈负相关。
DOI：
10.1080/01635581.2016.1134596
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Chun,OckK
中科院分区：
文献类型：
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作者：
Vance,TerrenceM;Wang,Ying;Su,LJoseph;Fontham,ElizabethTH;Steck,SusanE;Arab,Lenore;Bensen,JeannetteT;Mohler,JamesL;Chen,Ming-Hui;Chun,OckK
本研究的目的是确定北卡罗来纳州-路易斯安那州前列腺癌项目 (PCaP) 中 855 名非裔美国人 (AA) 和 945 名欧洲裔美国人 (EA) 中饮食和补充剂的总抗氧化能力 (TAC) 与前列腺癌侵袭性之间的关系。病例被分为高攻击性、低攻击性或中攻击性。 TAC 是通过食物频率调查问卷测量的 42 种抗氧化剂的维生素 C 当量抗氧化能力计算得出的。 EA 报告称，饮食和补充剂相结合的膳食 TAC 较高（P < 0.0001）。在最低限度和完全调整的逻辑回归模型中，饮食和补充剂组合的 TAC 与所有男性、AA 和 EA 中高侵袭性前列腺癌的发病率降低相关：最高水平与最低水平的比值比（>1500 与 <500 mg 维生素 C 当量/天）：0.31 [95% 置信区间 (CI)：0.15、0.67；P 趋势 < 0.01]、0.28 （95% CI：0.08、0.96；P 趋势 < 0.001）和 0.36（95% CI：0.15、0.86；P 趋势 = 0.58）。这些关联在 AA 和 EA 之间似乎没有差异。这些数据表明，摄入更多的抗氧化剂与侵袭性较低的前列腺癌相关。需要更多的研究来证实这些结果并确定潜在的机制。
The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina–Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P< 0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: odds ratios for highest vs. lowest level (>1500 vs. <500 mg vitamin C equivalent/day): 0.31 [95% confidence interval (CI): 0.15, 0.67;P-trend < 0.01], 0.28 (95% CI: 0.08, 0.96;P-trend < 0.001), and 0.36 (95% CI: 0.15, 0.86;P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.