Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging
Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging
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DOI：
10.1016/j.plefa.2016.10.001
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发表时间：
2016-11-01
影响因子：
3
通讯作者：
Videla, Luis A.
中科院分区：
文献类型：
--
作者：
Echeverria, Francisca;Ortiz, Macarena;Videla, Luis A.
过氧化物酶体增殖物激活受体（PPARs）是一种核受体，作为配体依赖性转录因子发挥作用，可被不同类型的脂肪酸（FA）激活。已经鉴定了PPARs的三种同种型，即PPARa、PPARp β/δ和PPARy，它们能够结合长链多不饱和FA（LCPUFA），n-3 LCPUFA以更大的亲和力结合以实现活化。FA结合会诱导核受体的构象变化，触发特定基因的转录，包括编码各种代谢和细胞过程（例如FA β氧化和脂肪生成）的基因，从而代表脂质稳态的关键介体。此外，PPARs在胎盘、胚胎和胎儿发育过程中，以及在与衰老相关的过程（包括氧化应激、炎症和神经保护）的调节中具有重要作用。本综述的目的是评估FM作为PPARs配体的作用，其主要功能与FA代谢及其在人类寿命期间相关病理学的预防和治疗中的相关性。
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-dependent transcription factors that can be activated by different types of fatty acids (FAs). Three isoforms of PPARs have been identify, namely, PPAR alpha, PPARp beta/delta, and PPAR gamma, which are able to bind long-chain polyunsaturated FAs (LCPUFAs), n-3 LCPUFAs being bound with greater affinity to achieve activation. FA binding induces a conformational change of the nuclear receptors, triggering the transcription of specific genes including those encoding for various metabolic and cellular processes such as FA beta-oxidation and adipogenesis, thus representing key mediators of lipid homeostasis. In addition, PPARs have important roles during placental, embryonal, and fetal development, and in the regulation of processes related to aging comprising oxidative stress, inflammation, and neuroprotection. The aim of this review was to assess the role of FM as PPARs ligands, in terms of their main functions associated with FA metabolism and their relevance in the prevention and treatment of related pathologies during human life span.