Drug Delivery Systems, Mitochondria-Targeted.
Drug Delivery Systems, Mitochondria-Targeted.
复制标题
线粒体靶向药物输送系统。
DOI：
10.1081/e-ebpp-120050056
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
and Harashima H.
中科院分区：
文献类型：
--
作者：
Yamada Y.;and Harashima H.
各种类型的线粒体功能障碍最近已被牵连在各种人类疾病。因此，该细胞器是一个有前途的治疗药物靶点，并且线粒体疗法将被期望用于治疗各种疾病。为了实现这种创新疗法，有必要将治疗剂递送到活细胞中的线粒体中。在本条目中，讨论了各种线粒体药物递送系统，包括亲脂性阳离子、肽缀合物、RNA缀合物、复合颗粒和纳米囊泡。我们目前的努力，针对发展的线粒体波特，脂质体为基础的载体线粒体delivery通过膜融合，也进行了讨论。
Various types of mitochondrial dysfunction have recently been implicated in a variety of human diseases. Therefore, this organelle is a promising therapeutic drug target, and mitochondrial therapy would be expected to be useful and productive for the treatment of various diseases. To achieve such an innovative therapy, it will be necessary to deliver therapeutic agents into mitochondria in living cells. In this entry, various mitochondrial drug delivery systems including lipophilic cations, peptide conjugates, RNA conjugates, complexed particles, and nano vesicles are discussed. Our current efforts directed toward the development of a MITO-Porter, a liposome-based carrier for mitochondrial deivery via membrane fusion, are also discussed.