NUSAP1 promotes invasion and metastasis of prostate cancer.
NUSAP1 promotes invasion and metastasis of prostate cancer.
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DOI：
10.18632/oncotarget.15604
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发表时间：
2017-05-02
期刊：
影响因子：
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通讯作者：
Brooks JD
中科院分区：
文献类型：
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作者：
Gordon CA;Gong X;Ganesh D;Brooks JD
我们先前已经确定核仁和纺锤体相关蛋白1(NUSAP1)是前列腺癌早期预后的生物标志物。为了更好地了解NUSAP1在前列腺癌进展中的作用，我们在细胞系、体内模型和患者样本中测试了NUSAP1表达增加和减少的影响。NUSAP1可能通过调节具有序列相似性的家族成员B(FAM101B)促进侵袭、迁移和转移，FAM101B是一种参与上皮向间充质转化的转化生长因子β1(β1)信号效应因子。我们的发现提供了对NUSAP1在前列腺癌进展中的重要性的洞察，并为进一步研究NUSAP1的功能、调节和临床应用提供了理论基础。
We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 (TGFβ1) signaling effector involved in the epithelial to mesenchymal transition. Our findings provide insights into the importance of NUSAP1 in prostate cancer progression and provide a rationale for further study of NUSAP1 function, regulation, and clinical utility.