Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation
Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation
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DOI：
10.1016/j.ijpsycho.2012.10.012
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发表时间：
2013-01-01
影响因子：
3
通讯作者：
Craske, Michelle G.
中科院分区：
文献类型：
--
作者：
Pittig, Andre;Arch, Joanna J.;Craske, Michelle G.
目前尚不清楚是否可以在焦虑症中发现高频心率变异性（HF-HRV）降低。在基线和焦虑应激期间，相对于健康对照，检查惊恐（PD）、广泛性焦虑（GAD）、社交焦虑（SAD）和强迫症（OCD）患者的HF-HRV和心率（HR）。相对于对照组，所有疾病均显示基线HF-HRV降低。基线HRV差异在整个放松过程中保持不变。对于过度换气，PD和GAD表现出比对照组更大的HR。除强迫症外，精神药物治疗不能解释HF-HRV的差异。年龄和性别证明了多个主效应。研究结果表明，低基线HF-HRV代表了PD，GAD和SAD抑制缺陷的共同指标，这与焦虑症中自主神经功能障碍的概念一致。然而，对过度换气的HR反应升高是PD和GAD特有的。(C)2012爱思唯尔有限公司版权所有。
It remains unclear if diminished high frequency heart rate variability (HF-HRV) can be found across anxiety disorders. HF-HRV and heart rate (HR) were examined in panic (PD), generalized anxiety (GAD), social anxiety (SAD), and obsessive-compulsive disorder (OCD) relative to healthy controls at baseline and during anxiety stressors. All disorders evidenced diminished baseline HF-HRV relative to controls. Baseline HRV differences were maintained throughout relaxation. For hyperventilation, PD and GAD demonstrated greater HR than controls. Psychotropic medication did not account for HF-HRV differences except in OCD. Age and sex evidenced multiple main effects. Findings suggest that low baseline HF-HRV represents a common index for inhibitory deficits across PD, GAD, and SAD, which is consistent with the notion of autonomic inflexibility in anxiety disorders. Elevated HR responses to hyperventilation, however, are specific to PD and GAD. (C) 2012 Elsevier B.V. All rights reserved.