Viral measurement by polymerase chain reaction-based assays in human immunodeficiency virus-infected infants.
Viral measurement by polymerase chain reaction-based assays in human immunodeficiency virus-infected infants.
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通过基于聚合酶链反应的检测对人类免疫缺陷病毒感染的婴儿进行病毒测量。
DOI：
10.1016/s0022-3476(95)70357-8
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Oleske,JM
中科院分区：
文献类型：
--
作者：
Palumbo,PE;Kwok,S;Waters,S;Wesley,Y;Lewis,D;McKinney,N;Bardeguez,A;Connor,EM;Oleske,JM
通过定量人类免疫缺陷病毒聚合酶链反应分析对出生第一年感染人类免疫缺陷病毒的婴儿的系列样本进行分析。在整个研究期间检测到血浆 RNA 和前病毒 DNA 水平持续非常高，表明缺乏有效的免疫反应。尽管病毒复制水平很高，但大多数患者的 CD4 淋巴细胞计数正常，并且在前 3 至 6 个月内没有任何症状。这些发现支持早期干预（在症状出现之前）的评估以及建立这些检测的预测价值的努力。 （儿科杂志 1995；126：592-5）
Serial samples from human immunodeficiency virus-infected infants in the first year of life were analyzed by quantitative human immunodeficiency virus polymerase chain reaction assays. Very high, persistent levels of plasma RNA and proviral DNA were detected throughout the study period, suggesting the absence of an effective immune response. Most patients had normal CD4 lymphocyte counts and were symptom free for the first 3 to 6 months despite high levels of viral replication. These findings support the evaluation of early intervention (before symptoms develop) and efforts to establish the predictive value of these assays. (J PEDIATR 1995;126:592-5)