Genomic polymorphism in the population of Candida glabrata: Gene copy-number variation and chromosomal translocations
Genomic polymorphism in the population of Candida glabrata: Gene copy-number variation and chromosomal translocations
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DOI：
10.1016/j.fgb.2008.11.006
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发表时间：
2009-03-01
影响因子：
3
通讯作者：
Fairhead, Cecile
中科院分区：
文献类型：
--
作者：
Muller, Heloise;Thierry, Agnes;Fairhead, Cecile
自2004年以来，人类机会主义病原体光滑假丝酵母菌模式株(CBS138，ATCC 2001)的基因组序列已经公布。这使得通过比较基因组杂交来分析其他菌株的基因组结构成为可能。我们在这里介绍了从法国和世界各地住院的患者分离的183株光滑C菌的分子分析。我们发现，在这种无性物种中的微进化机制包括罕见的染色体相互易位和重复基因串联阵列内的重组，这些都解释了不同品系染色体之间频繁的大小异质性。基因突变体通常编码细胞壁蛋白，这表明它可能在适应环境中发挥作用。(C)2008 Elsevier Inc.保留所有权利。
The genomic sequence of the type strain of the opportunist human pathogen Candida glabrata (CBS138, ATCC 2001) is available since 2004. This allows the analysis of genomic structure of other strains by comparative genomic hybridization. We present here the molecular analysis of a collection of 183 C glabrata strains isolated from patients hospitalized in France and around the world. We show that the mechanisms of microevolution within this asexual species include rare reciprocal chromosomal translocations and recombination within tandem arrays of repeated genes, and that these account for the frequent size heterogeneity between chromosomes across strains. Gene tandems often encode cell wall proteins suggesting a possible role in adaptation to the environment. (C) 2008 Elsevier Inc. All rights reserved.