ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
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DOI：
10.1016/j.febslet.2008.12.063
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发表时间：
2009-02-04
期刊：
影响因子：
3.5
通讯作者：
Shirasawa, Senji
中科院分区：
文献类型：
--
作者：
Fujimoto, Takahiro;Doi, Keiko;Shirasawa, Senji
ZFAT（也称为ZNF 406）最初被鉴定为自身免疫性甲状腺疾病的候选基因，其编码锌指蛋白，然而其功能尚未阐明。在这里，我们报告，人ZFAT蛋白表达在外周B和T淋巴细胞和人急性T淋巴细胞白血病细胞系，MOLT-4细胞。有趣的是，在原始细胞形成过程中，小鼠CD 4（+）淋巴细胞中的ZFAT表达增加。此外，MOLT-4中的ZFAT敲低通过激活半胱氨酸蛋白酶诱导细胞凋亡。这些结果表明，ZFAT蛋白是参与免疫相关细胞凋亡和细胞存活的关键调节因子。(c)2009年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4(+) lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.