Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
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DOI：
10.1016/j.jinorgbio.2010.08.014
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发表时间：
2011-03-01
影响因子：
3.9
通讯作者：
Albrecht-Gary, Anne-Marie
中科院分区：
文献类型：
--
作者：
Budimir, Ana;Humbert, Nicholas;Albrecht-Gary, Anne-Marie
我们报道了一种治疗阿尔茨海默病的恶唑类神经活性药物CLOQOL与生物相关的二价金属离子(铜、锌、镍、钴和锰)的配位性质的全面物理化学研究。利用电喷雾质谱、吸收光谱和电位法的有效结合，我们表征了单络合和双络合金属离子物种。稳定常数的测定显示了所研究系列的经典热力学行为，其中铜络合物是迄今为止最稳定的物种。我们的数据是在阿尔茨海默病的范围内讨论的。(C)2010 Elsevier Inc.保留所有权利。
We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease. (C) 2010 Elsevier Inc. All rights reserved.