Synergistic Role of Quantitative Diffusion Magnetic Resonance Imaging and Structural Magnetic Resonance Imaging in Predicting Outcomes After Traumatic Brain Injury.
Synergistic Role of Quantitative Diffusion Magnetic Resonance Imaging and Structural Magnetic Resonance Imaging in Predicting Outcomes After Traumatic Brain Injury.
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DOI：
10.1097/rct.0000000000001284
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发表时间：
2022-03-01
影响因子：
1.3
通讯作者：
Gupta R
中科院分区：
文献类型：
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作者：
Avesta A;Yendiki A;Perlbarg V;Velly L;Khalilzadeh O;Puybasset L;Galanaud D;Gupta R
评估定量弥散MRI分析是否能改善重度创伤性脑损伤患者个体的诊断。我们分析了30名健康对照的图像，以提取沿沿着18条白质束的正常各向异性分数（FA）范围。然后，我们分析了33例患者的图像，将他们的FA值与从对照组提取的正常范围进行比较，并计算白质束损伤的严重程度。我们还要求两位神经放射科医生在FLAIR和SWI图像上对不同脑区的损伤严重程度进行评级。最后，我们建立了三个模型：1）以神经放射学家的评级为基础; 2）以白质损伤指标为基础; 3）以两种输入类型为基础。三种模型预测1年生存率的准确率分别为70%、73%和88%。两种输入方式的正确率均显著高于其他输入方式（P<0.05）。量化白质束损伤的严重程度补充了定性成像结果，并改善了严重创伤性脑损伤的预后预测。
to assess if quantitative diffusion MRI analysis would improve prognostication of individual patients with severe traumatic brain injury. we analyzed images of 30 healthy controls to extract normal Fractional Anisotropy (FA) ranges along 18 white-matter tracts. Then, we analyzed images of 33 patients, compared their FA values with normal ranges extracted from controls, and computed severity of injury to white-matter tracts. We also asked two neuroradiologists to rate severity of injury to different brain regions on FLAIR and SWI images. Finally, we built three models: 1) fed with neuroradiologists’ ratings; 2) fed with white-matter injury measures; and 3) fed with both input types. the three models respectively predicted survival at 1 year with accuracies of 70%, 73%, and 88%. The accuracy with both input types was significantly better (P<0.05). quantifying severity of injury to white-matter tracts complements qualitative imaging findings and improves outcome prediction in severe traumatic brain injury.