Erythrocyte-Membrane-Coated Prussian Blue/Manganese Dioxide Nanoparticles as H2O2-Responsive Oxygen Generators To Enhance Cancer Chemotherapy/Photothermal Therapy
Erythrocyte-Membrane-Coated Prussian Blue/Manganese Dioxide Nanoparticles as H2O2-Responsive Oxygen Generators To Enhance Cancer Chemotherapy/Photothermal Therapy
复制标题
红细胞膜包被的普鲁士蓝/二氧化锰纳米颗粒作为 H2O2 响应性氧气发生器，增强癌症化疗/光热治疗
DOI：
10.1021/acsami.7b17022
复制
发表时间：
2017-12-27
影响因子：
9.5
通讯作者：
Qian, Zhiyong
中科院分区：
文献类型：
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作者：
Peng, Jinrong;Yang, Qan;Qian, Zhiyong
由于抗癌药物的非靶向释放，常规化疗导致严重的副作用和不良的治疗效果。此外，肿瘤微环境中的缺氧状况也促进了肿瘤的生长和转移。具有刺激激活和缺氧缓解特性的多功能纳米载体可以帮助克服这些限制。在本研究中，我们构建了一种纳米载体，命名为PBMn DOX@RBC。普鲁士蓝/二氧化锰（PBMn）纳米颗粒被用作H2 O2活化的氧前体或催化剂，并且红细胞（RBC）膜被用于增加阿霉素（DOX）的负载能力并延长体内循环时间。H2 O2在肿瘤组织和肿瘤细胞中过量产生。它可以用作刺激物来激活药物释放。在H2 O2存在下，通过施用PBMn DOX@RBC缓解肿瘤内的缺氧。产生的氧气破坏了PBMn表面的RBC，加速了DOX的释放。红细胞还延长了纳米系统在体内的循环时间。通过将光热疗法（PTT）与化疗相结合，进一步增强了PBMn DOX@RBC介导的肿瘤生长抑制。PBMn DOX@RBC满足缓解肿瘤缺氧和增强癌症化疗/PTT的需求。
Because of the nontargeting release of anticancer drugs, conventional chemotherapy results in serious side effects and poor therapeutic outcomes. In addition, hypoxia situation in the tumor microenvironment also promotes the growth and metastasis of tumors. Multifunctional nanocarriers with stimuli-activation and hypoxia-relieving properties can help overcome some of these limitations. In this study, we have constructed a nanocarrier which is named PBMn DOX@RBC. A Prussian blue/manganese dioxide (PBMn) nanoparticle is used as an oxygen precursor or catalyzer for H2O2 activation, and a red blood cell (RBC) membrane is used to increase the loading capacity of doxorubicin (DOX) and prolong the circulation time in vivo. H2O2 is overproduced in tumor tissues and tumor cells. It can be used as a stimulus to activate drug release. In the presence of H2O2, the hypoxia inside the tumors is relieved by the administration of PBMn DOX@RBC. The generated oxygen disrupts the RBC coated on the surface of PBMn, which accelerates the release of DOX. RBCs also prolong the circulation time of the nanometer system in vivo. By combining the photothermal therapy (PTT) and chemotherapy, the tumor growth inhibition mediated by PBMn DOX@RBC is further enhanced. PBMn DOX@RBC fulfills the demands to relieve tumor hypoxia and enhance cancer chemotherapy/PTT.