A dose voxel kernel method for rapid reconstruction of out-of-field neutron dose of patients in pencil beam scanning (PBS) proton therapy.
A dose voxel kernel method for rapid reconstruction of out-of-field neutron dose of patients in pencil beam scanning (PBS) proton therapy.
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DOI：
10.1088/1361-6560/abaa5f
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发表时间：
2020-08-27
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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蒙特卡罗 (MC) 辐射传输方法被用作剂量计算的“黄金标准”。然而，该方法计算耗时，因此对于后期健康影响的流行病学调查所需的大量质子治疗患者的正常组织剂量重建来说是不切实际的。在本研究中，我们开发了一种新的剂量计算方法，用于快速重建接受笔形束扫描（PBS）质子治疗的患者的场外中子剂量。新的剂量计算方法基于对质子笔形束照射水体模（60 × 60 × 300 cm3）进行 MC 模拟生成的中子剂量体素核 (DVK)，该模拟是使用 MC 质子治疗模拟代码 TOPAS 进行的。 DVK 是针对 19 种光束能量（从 70 到 250 MeV，间隔为 10 MeV）和三种量程移位器厚度（1、3 和 5 cm）生成的。内部程序是用 C++ 编写的，根据治疗计划中可用的质子束特征（能量、位置和方向）将 DVK 叠加到患者 CT 图像上。通过计算模拟颅内和颅脊髓照射的 1 岁和 5 岁全身计算模型的器官/组织特异性中子剂量来测试 DVK 剂量计算方法。基于 DVK 的剂量通常与先前发表的通过详细 PBS 模型进行直接 MC 模拟计算得出的剂量基本一致，颅内和颅脊髓照射的差异大多分别小于 30% 和 10%。 DVK 方法在个人计算机的单个 CPU 核心上对一名患者的计算时间为 1 至 30 分钟，与在高性能计算服务器上需要数天的直接 MC 剂量计算相比，显示出显着的改进。当需要对大量患者进行剂量测定（例如流行病学或临床研究）时，我们基于 DVK 的剂量计算方法将非常有用。
Monte Carlo (MC) radiation transport methods are used for dose calculation as ‘gold standard.’ However, the method is computationally time-consuming and thus impractical for normal tissue dose reconstructions for the large number of proton therapy patients required for epidemiologic investigations of late health effects. In the present study, we developed a new dose calculation method for the rapid reconstruction of out-of-field neutron dose to patients undergoing pencil beam scanning (PBS) proton therapy. The new dose calculation method is based on neutron dose voxel kernels (DVKs) generated by MC simulations of a proton pencil beam irradiating a water phantom (60 × 60 × 300 cm3), which was conducted using a MC proton therapy simulation code, TOPAS. The DVKs were generated for 19 beam energies (from 70 to 250 MeV with the 10-MeV interval) and three range shifter thicknesses (1, 3, and 5 cm). An in-house program was written in C++ to superimpose the DVKs onto a patient CT images according to proton beam characteristics (energy, position, and direction) available in treatment plans. The DVK dose calculation method was tested by calculating organ/tissue-specific neutron doses of 1- and 5-year-old whole-body computational phantoms where intracranial and craniospinal irradiations were simulated. The DVK-based doses generally showed reasonable agreement with those calculated by direct MC simulations with a detailed PBS model that were previously published, with differences mostly less than 30% and 10% for the intracranial and craniospinal irradiations, respectively. The computation time of the DVK method for one patient ranged from 1 to 30 minutes on a single CPU core of a personal computer, demonstrating significant improvement over the direct MC dose calculation requiring several days on high-performance computing servers. Our DVK-based dose calculation method will be useful when dosimetry is needed for the large number of patients such as for epidemiologic or clinical research.
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影响因子：
2.1
作者：
Langner, Ulrich W.;Eley, John G.;Langen, Katja
通讯作者：
Langen, Katja
影响因子：
3.5
作者：
Shin, Wook-Geun;Testa, Mauro;Min, Chul Hee
通讯作者：
Min, Chul Hee
影响因子：
1.4
作者：
Hartman, J.;Zhang, X.;Raaymakers, B. W.
通讯作者：
Raaymakers, B. W.
影响因子：
3.4
作者：
Kuzmin, Gleb A.;Mille, Matthew M.;Lee, Choonsik
通讯作者：
Lee, Choonsik
DOI：
10.1016/j.nima.2016.06.125
发表时间：
2016-11-01
影响因子：
1.4
作者：
Allison, J.;Amako, K.;Yoshida, H.
通讯作者：
Yoshida, H.