Increased CD4(+)CD8(+) Double Positive T Cells during Hantaan Virus Infection.
Increased CD4(+)CD8(+) Double Positive T Cells during Hantaan Virus Infection.
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汉坦病毒感染期间 CD4 CD8 双阳性 T 细胞增加
DOI：
10.3390/v14102243
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发表时间：
2022-10-13
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhang H;Wang Y;Ma Y;Tang K;Zhang C;Wang M;Zhang X;Xue M;Jia X;Hu H;Li N;Zhuang R;Jin B;Chen L;Zhang Y;Zhang Y
Hantaan virus (HTNV) infection causes an epidemic of hemorrhagic fever with renal syndrome (HFRS) mainly in Asia. It is well known that T cells mediated anti-viral immune response. Although previous studies showed that double positive T (DP T) cells, a little portion of T lymphocytes, were involved in adaptive immune response during virus infection, their kinetic changes and roles in HTNV infection have not yet been explored. In this study, we characterized DP T cells from HFRS patients based on flow cytometry data combined with scRNA-seq data. We showed that HTNV infection caused the upregulation of DP T cells in the peripheral blood, which were correlated with disease stage. The scRNA-seq data clustered DP T cells, unraveled their gene expression profile, and estimated the ordering of these cells. The production of granzyme B and CD107a from DP T cells and the abundant TCR distribution indicated the anti-viral property of DP T cells. In conclusion, this study identified, for the first time, an accumulation of DP T cells in the peripheral blood of HFRS patients and suggested these DP T cells belonging to CD8+T cells lineage. The DP T cells shared the similar characteristics with cytotoxic T cells (CTL) and exerted an anti-viral role in HFRS.
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CD8( ) T 细胞的 HTNV 感染与 HFRS 患者的疾病进展相关
影响因子：
5.9
作者：
Liu R;Ma R;Liu Z;Hu H;Shu J;Hu P;Kang J;Zhang Y;Han M;Zhang X;Zheng Y;Ying Q;Hou S;Wang W;Wang F;Cheng N;Zhuang Y;Lian J;Jin X;Wu X
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Wu X
影响因子：
7.3
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Chen, Yongyuan;Xin, Zhongwei;Chai, Ying
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Chai, Ying
影响因子：
4.3
作者：
MACCHI, B;GRAZIANI, G;MASTINO, A
通讯作者：
MASTINO, A
影响因子：
64.8
作者：
LUSSO, P;DEMARIA, A;GALLO, RC
通讯作者：
GALLO, RC
影响因子：
3.7
作者：
Fang, Liqun;Yan, Lei;Liang, Song;de Vlas, Sake J.;Feng, Dan;Han, Xiaona;Zhao, Wenjuan;Xu, Bing;Bian, Ling;Yang, Hong;Gong, Peng;Richardus, Jan Hendrik;Cao, Wuchun
通讯作者：
Cao, Wuchun