INTERRELATIONSHIPS BETWEEN SEX HORMONE-BINDING GLOBULIN AND TESTOSTERONE, 5-ALPHA-DIHYDROTESTOSTERONE AND OESTRADIOL-17-BETA IN BLOOD OF NORMAL MEN
INTERRELATIONSHIPS BETWEEN SEX HORMONE-BINDING GLOBULIN AND TESTOSTERONE, 5-ALPHA-DIHYDROTESTOSTERONE AND OESTRADIOL-17-BETA IN BLOOD OF NORMAL MEN
复制标题
DOI：
10.1016/0378-5122(80)90044-4
复制
发表时间：
1980-01-01
期刊：
影响因子：
4.9
通讯作者：
BARTSCH, W
中科院分区：
文献类型：
--
作者：
BARTSCH, W
性激素结合球蛋白（SHBG），睾酮（T），5 α-双氢睾酮（DHT）和17 β-本文测定了93例36-80岁男性血清雌二醇（E_2）水平。假设类固醇与血白蛋白和SHBG的结合遵循质量作用定律，根据SHBG和相应的总激素值计算非SHBG结合的类固醇浓度（Tn，DHTn，E2 n）。Tn、DHTn、E2 n和SHBG的平均值在65岁之前保持恒定水平。与36-55岁男性相比，66-80岁男性的Tn和DHTn显著降低（P < 0.001），而E2 n和SHBG升高（分别为P < 0.05，P < 0.001）。与SHBG呈正相关的是总T和DHT I组（P < 0.001）（年龄36-55岁）以及消除年龄影响时Ⅱ组T、DHT、E2分别为P <0.05、P <0.01、P < 0.01在年龄56-80岁组中，Tn与SHBG无显著相关性，而DHTn与SHBG呈负相关（P < 0.01）。组II中SHBG的年龄依赖性增加可以通过E2 n：DHTn比率的相应改变来最好地解释。这些结果进行了讨论与SHGB，总类固醇和非SHBG结合类固醇浓度之间的关系。
Sex hormone-binding globulin (SHBG), testosterone (T), 5.alpha.-dihydrotestosterone (DHT) and 17.beta.-estradiol (E2) were measured in 93 men in the age range 36-80 yr. Assuming that the binding of the steroids to blood albumin and SHBG follows the law of mass action, non-SHBG bound steroid concentrations (Tn, DHTn, E2n) were calculated from the SHBG and the respective total hormone values. Mean Tn, DHTn, E2n and SHBG remained on a constant level until the age of 65 yr. In men 66-80 yr old Tn and DHTn were significantly lower (P < 0.001), whereas E2n and SHBG were elevated (P < 0.05, P < 0.001, respectively) when compared with men age 36-55 yr. In contrast to total T and DHT, which correlated positively with SHBG (P < 0.001) in Group I (age 36-55 yr) and also when eliminating the influence of age (P < 0.05, P < 0.01, P < 0.01 for T, DHT and E2) in Group II (age 56-80 yr), the correlation between Tn and SHBG was insignificant; a negative correlation between DHTn and SHBG (P < 0.01) was present in Group I. The age-dependent increase of SHBG in Group II can be best explained by the respective alterations of the E2n: DHTn ratio. These results are discussed with respect to the relation between the SHGB, the total steroid and the non-SHBG bound steroid concentrations.