Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments
Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments
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钙蛋白酶抑制剂作为中风和其他神经退行性疾病的潜在治疗方法：最新趋势和发展
DOI：
10.1517/13543776.8.12.1707
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发表时间：
1998
影响因子：
6.6
通讯作者：
R. Bihovsky
中科院分区：
文献类型：
--
作者：
G. Wells;R. Bihovsky
Calpain, a calcium-activated cysteine protease present in most mammalian tissues, including the brain, has been implicated in neurodegenerative processes resulting from its overactivation following cerebral ischaemia or traumatic injury to the head or spinal cord. Through significant effort, particularly over the past ten to fifteen years, the complex biochemistry and physiological roles of this important regulatory enzyme have been partially clarified. Despite remarkable advances in understanding calpain’s normal functions, as well as its involvement in neuropathological conditions, a full appreciation of its role in neuronal cells remains elusive. A wide array of peptidic, peptide mimetic and non-peptide inhibitors have recently emerged, some of which display potency both in vitro and in vivo in various cell lines and animal models of focal and global ischaemia. A drug candidate has yet to be identified for advancement to clinical testing.
氨肽酶的α-酮酰胺抑制剂。
影响因子：
7.3
作者：
Ocain,TD;Rich,DH
通讯作者：
Rich,DH
DOI：
10.1073/pnas.88.16.7233
发表时间：
1991-08-01
影响因子：
11.1
作者：
LEE, KS;FRANK, S;LYNCH, G
通讯作者：
LYNCH, G
通过由激肽原和 S-(3-硝基-2-吡啶硫基)-半胱氨酸的硫醇蛋白酶抑制序列衍生的合成肽抑制钙蛋白酶来调节凝血酶诱导的血小板聚集。
DOI：
10.1111/j.1432-1033.1993.tb17916.x
发表时间：
1993
期刊：
European journal of biochemistry
影响因子：
--
作者：
Puri,RN;Matsueda,R;Umeyama,H;Bradford,HN;Colman,RW
通讯作者：
Colman,RW