An association between dopamine D4 receptor and transporter gene polymorphisms and personality traits, assessed using NEO-FFI in a Polish female population
An association between dopamine D4 receptor and transporter gene polymorphisms and personality traits, assessed using NEO-FFI in a Polish female population
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DOI：
10.1016/j.paid.2007.01.001
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发表时间：
2007-08-01
影响因子：
4.3
通讯作者：
Oniszczenko, Wlodzimierz
中科院分区：
文献类型：
--
作者：
Dragan, Wojciech L.;Oniszczenko, Wlodzimierz
我们寻找DRD4外显子III和3 ' UTR DAT1多态性与200名无血缘关系的波兰裔年轻女性的人格特征之间的关联。使用NEO-FFI问卷测量人格特征。DRD4基因的7重复变体与较低水平的责任心相关（F = 4.69, df = 1, p = 0.032, Cohen's F = 0.16）。此外，DRD4和DAT1多态性与神经质之间存在显著的交互作用（F = 3.92, df = 1, p = 0.049, Cohen's F = 0.14）。需要进一步的研究来解释多巴胺能系统基因变异的作用，以及它如何影响人格特征的发展。(c) 2007 Elsevier Ltd.版权所有。
We looked for an association between the DRD4 exon III and 3 ' UTR DAT1 polymorphisms and the personality traits of 200 unrelated young women of Polish descent. Personality traits were measured using the NEO-FFI questionnaire. The 7-repeat variant of the DRD4 gene was associated with a lower level of conscientiousness (F = 4.69, df = 1, p = 0.032, Cohen's f = 0.16). In addition, a statistically significant interaction was observed between the DRD4 and DAT1 polymorphisms with respect to neuroticism (F = 3.92, df = 1, p = 0.049, Cohen's f = 0.14). Further research is required to explain the role of variability in the dopaminergic system genes and how this affects the development of personality traits. (c) 2007 Elsevier Ltd. All rights reserved.