PERSISTENT RUBELLA-VIRUS INFECTION ASSOCIATED WITH CHRONIC ARTHRITIS IN CHILDREN
PERSISTENT RUBELLA-VIRUS INFECTION ASSOCIATED WITH CHRONIC ARTHRITIS IN CHILDREN
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DOI：
10.1056/nejm198510313131803
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
PETTY, RE
中科院分区：
文献类型：
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作者：
CHANTLER, JK;TINGLE, AJ;PETTY, RE
我们从 19 名慢性风湿病儿童中的 7 名的淋巴网状细胞中分离出风疹病毒，这些儿童包括全身性幼年类风湿性关节炎（斯蒂尔氏病）（5 名中的 1 名）、多关节型幼年类风湿性关节炎（2 名中的 2 名）、少关节型幼年类风湿性关节炎（6 名中的 2 名）和血清阴性脊柱关节炎患者（6 名中的 2 名）。相比之下，对照组中没有分离到风疹病毒，该对照组包括八名正常受试者和八名患有其他结缔组织疾病或创伤性关节积液的患者。在研究组的大多数成员中，检查了来自滑液和外周血的单核细胞。从三名患者的两种细胞群中分离出风疹病毒，一名患者仅从外周血中分离出风疹病毒，两名患者仅从滑液中分离出风疹病毒。在患有全身性幼年类风湿性关节炎的儿童中，仅检查了外周血，在分析的五个样本中，其中一个显示出风疹病毒。七人中有四人不止一次分离出病毒。在 35% 的幼年关节炎病例中，风疹病毒在淋巴网状细胞中持续存在，这支持了该病毒可能是人类慢性关节病的病因的观点，但需要进一步的工作来支持这一建议。
We isolated rubella virus from lymphoreticular cells in 7 of 19 children with chronic rheumatic disease, including patients with systemic-onset juvenile rheumatoid arthritis (Still''s disease) (1 of 5), polyarticular juvenile rheumatoid arthritis (2 of 2), pauciarticular juvenile rheumatoid arthritis (2 of 6), and seronegative spondyloarthritis (2 of 6). In contrast, rubella virus was not isolated from the control group, which included eight normal subjects and eight patients with other connective tissue diseases or traumatic joint effusion. In most members of the study group, mononuclear cells from both synovial fluid and peripheral blood were examined. Rubella virus was isolated from both cell populations in three patients, from only peripheral blood in one, and from only synovial fluid in two. In the children with systemic-onset juvenile rheumatoid arthritis, only peripheral blood was examined, and of the five samples analyzed, one was shown to have rubella virus. Virus was isolated on more than one occasion from four of seven persons. Persistence of rubella virus in lymphoreticular cells in 35% of these cases of juvenile arthritis supports the view that the virus may be an etiologic agent in chronic human joint disease, but further work will be required to support this suggestion.