Development of patient-specific molecular imaging phantoms using a 3D printer
Development of patient-specific molecular imaging phantoms using a 3D printer
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DOI：
10.1118/1.4887854
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发表时间：
2014-08-01
期刊：
影响因子：
3.8
通讯作者：
Flux, G. D.
中科院分区：
文献类型：
--
作者：
Gear, J. I.;Long, C.;Flux, G. D.
目的：本研究的目的是探索快速成型技术，以直接从患者的CT数据中生产出针对患者的、具有成本效益的液体可填充体模。每个器官都被转换成一个外壳，并使用计算机辅助设计软件添加填充孔和腿部支架，并准备打印。在肝脏上增加了额外的固定装置，以便将病变插入物固定在结构内。使用PolyJet技术在Objet Eden 500V 3D打印机上用紫外光固化聚合物打印模体。结果：最终的打印材料是透明的固体丙烯酸塑料，防水、坚硬，足够耐用，可以承受多种组装和扫描方案。用~(99m)Tc-SPECT和F-18PET/CT对模型进行了初步扫描。结论：器官几何形态与解剖学参考文献具有较好的一致性。所开发的方法学可普遍应用于其他解剖或几何模体的分子成像。(C)2014年美国医学物理学家协会。
Purpose: The aim of the study was to investigate rapid prototyping technology for the production of patient-specific, cost-effective liquid fillable phantoms directly from patient CT data.Methods: Liver, spleen, and kidney volumes were segmented from patient CT data. Each organ was converted to a shell and filling holes and leg supports were added using computer aided design software and prepared for printing. Additional fiXtures were added to the liver to allow lesion inserts to be fixed within the structure. Phantoms were printed from an ultraviolet curable photopolymer using polyjet technology on an Objet EDEN 500V 3D printer.Results: The final print material is a clear solid acrylic plastic which is watertight, rigid, and sufficiently durable to withstand multiple assembly and scanning protocols. Initial scans of the phantoms have been performed with Tc-99m SPECT and F-18 PET/CT.Conclusions: The organ geometry showed good correspondence with anatomical references. The methodology developed can be generally applied to other anatomical or geometrical phantoms for molecular imaging. (C) 2014 American Association of Physicists in Medicine.