Dutch Tariff for the Five-Level Version of EQ-5D
Dutch Tariff for the Five-Level Version of EQ-5D
复制标题
DOI：
10.1016/j.jval.2016.01.003
复制
发表时间：
2016-06-01
期刊：
影响因子：
4.5
通讯作者：
Stolk, Elly A.
中科院分区：
文献类型：
--
作者：
Versteegh, Matthijs M.;Vermeulen, Karin M.;Stolk, Elly A.
背景：2009 年，推出了新版 EuroQol 五维问卷 (EQ-5D)，每个维度有五个而不是三个答案级别。该仪器被称为 EQ-5D-5L。为了使 EQ-5D-5L 适合用于经济评估，需要将社会价值观附加到所有 3125 种健康状态。目标：得出 EQ-5D-5L 的荷兰关税。方法：使用复合时间权衡（cTTO）和离散选择实验（DCE），通过对按年龄、性别和教育程度分层的一般人群样本进行面对面访谈，得出健康状态值。使用普通最小二乘法和 tobit 回归（对于 cTTO）以及多项条件 Logit 模型（对于 DCE）对数据进行建模。模型性能是根据内部一致性、简约性、拟合优度、左删失值的处理和理论考虑来评估的。结果：荷兰人口的代表性样本（N = 1003）参与了评估研究。 cTTO 和 DCE 的分析中分别包含 979 名和 992 名受访者的数据。 cTTO 数据左删失为 -1。 Tobit 模型因其对数据审查性质的处理而被认为是电价的首选模型，这一点通过与 DCE 数据的比较得到证实。 EQ-5D-5L 的预测值范围为 -0.446 到 1。 结论：本研究根据 cTTO 确定了 EQ-5D-5L 的荷兰关税。这些值代表了荷兰人口的偏好。该费率可用于估计医疗保健干预措施对生活质量的影响，例如在经济评估中。
Background: In 2009, a new version of the EuroQol five-dimensional questionnaire (EQ-5D) was introduced with five rather than three answer levels per dimension. This instrument is known as the EQ-5D-5L. To make the EQ-5D-5L suitable for use in economic evaluations, societal values need to be attached to all 3125 health states. Objectives: To derive a Dutch tariff for the EQ-5D-5L. Methods: Health state values were elicited during face-to-face interviews in a general population sample stratified for age, sex, and education, using composite time trade-off (cTTO) and a discrete choice experiment (DCE). Data were modeled using ordinary least squares and tobit regression (for cTTO) and a multinomial conditional logit model (for DCE). Model performance was evaluated on the basis of internal consistency, parsimony, goodness of fit, handling of left-censored values, and theoretical considerations. Results: A representative sample (N = 1003) of the Dutch population participated in the valuation study. Data of 979 and 992 respondents were included in the analysis of the cTTO and the DCE, respectively. The cTTO data were left-censored at -1. The tobit model was considered the preferred model for the tariff on the basis of its handling of the censored nature of the data, which was confirmed through comparison with the DCE data. The predicted values for the EQ-5D-5L ranged from -0.446 to 1. Conclusions: This study established a Dutch tariff for the EQ-5D-5L on the basis of cTTO. The values represent the preferences of the Dutch population. The tariff can be used to estimate the impact of health care interventions on quality of life, for example, in context of economic evaluations.