Action of the colony-stimulating factor, CSF-1.
Action of the colony-stimulating factor, CSF-1.
复制标题
集落刺激因子 CSF-1 的作用。
DOI：
10.1002/9780470720998.ch3
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Stanley,ER
中科院分区：
文献类型：
--
作者：
Stanley,ER
阿西尔西特集落刺激因子1（CSF-I）是一种糖蛋白生长因子，其通过选择性表达在这些细胞类型上的细胞表面受体特异性地调节单核吞噬细胞及其前体的存活、增殖和分化。纯化的受体是; I单一糖基化多肽，M，16.5 000，其表现出CSF-1依赖性酪氨酸自磷酸化。CSF-I单独调节单核吞噬细胞系列（CSF-I依赖性集落形成单位[CFU-C]+单核母细胞-+前单核细胞-+单核细胞+巨噬细胞）的细胞。然而，多能造血细胞生长因子造血素-1的存在允许CSF-I刺激CFU-C的前体增殖并分化成巨噬细胞。CFU-C的前体细胞具有低水平的CSF-I受体，但在CFU-C分化为粘附的、增殖的单核吞噬细胞之前，CFU-C上的受体水平增加。由于这种发育相关的受体表达增加的时间与获得对单独CSF-I的反应性一致，因此它是确定单核细胞吞噬细胞谱系的早期指标。
Ahsircict. Colony-stimulating factor 1 (CSF-I) is a glycoprotein growth factor that specifically regulates the survival, prolifcration and differentiation of mononuclear phagocytes and their precursors via a cell surface receptor selectively expressed on these cell typcs.‘The purified receptor is; I single glycosylated polypeptide, M, 16.5 000, which exhibits CSF-1-dependent autophosphorylation in tyrosine. CSF-I alonc regulates cells of the mononuclear phagoeytic series (CSF-I-dependent colony-forming unit [CFU-C]+ monoblast-+ promonocyte-+ monocyte+ macrophage). However, the presence ol ‘a multipotent haemopoietic cell growth factor, haemopoietin-l, permits CSF-I to stimulate precursors of CFU-C to proliferate and differentiate to macrophages. Precursors of CFU-C possess low levels of the CSF-I receptor hut there is an increase in receptor levels on CFU-C just before their differentiation to adherent, proliferating mononuclear phagocytes. As the timing of this developmentally associated increase in receptor expression coincides with the acquisition of responsiveness to CSF-I alone, it is an early indicator ofdetermination to the mononuclcar phagocytic lineage.