Measles in bone marrow transplant recipients during an outbreak in Sao Paulo, Brazil
Measles in bone marrow transplant recipients during an outbreak in Sao Paulo, Brazil
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DOI：
10.1182/blood.v99.1.83
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发表时间：
2002-01-01
期刊：
影响因子：
20.3
通讯作者：
de Souza, VAUF
中科院分区：
文献类型：
--
作者：
Machado, CM;Gonçalves, FB;de Souza, VAUF
1997年，圣保罗爆发麻疹疫情。 2月至12月期间，确诊病例为20185例。 1997年4月至7月，进行了一项血清流行病学调查，以确定对麻疹易感的骨髓移植受者以及该人群中麻疹的发生情况。通过酶免疫分析（EIA）对总共156名患者进行了筛查。 IgG 滴度超过 100 mIU/mL 的患者被认为具有免疫力。还审查了麻疹重新免疫记录。三十二名接种疫苗的患者接受了血清学评估。 22 名患者中的 6 名 (27.3%) 在接种疫苗后 3 年内失去了麻疹免疫力，而 10 名患者中的 7 名 (70%) 接种疫苗时间超过 3 年 (P=.049)。在 122 名未接种疫苗的患者中，41 名（33.6%）对麻疹易感：47 名患者中的 4 名（8.5%）在骨髓移植（BMT）后第一年内，75 名患者中的 37 名（49.3%）在 BMT 后第一年后（P
In 1997, a measles outbreak was identified in Sio Paulo. Between February and December, 20 185 cases were confirmed. From April to July 1997, a seroepidemiologic survey was conducted to identify the recipients of bone marrow (BM) transplants who were susceptible to measles and the occurrence of measles in this population. A total of 156 patients were screened by enzyme immunoassay (EIA). Patients with IgG titers more than 100 mIU/mL were considered immune. Measles reimmunization records were also reviewed. Thirty-two vaccinated patients underwent serologic evaluation. Six of 22 patients (27.3%) within 3 years after vaccination lost measles immunity, in contrast to 7 of 10 patients (70%) vaccinated longer than 3 years previously (P=.049). Among the 122 nonvaccinated patients, 41 (33.6%) were susceptible to measles: 4 of 47 patients (8.5%) within the first year after BM transplantation (BMT), and 37 of the 75 patients (49.3%) after the first year after BMT (P