Socioeconomic status, hostility, and risk factor clustering in the normative aging study: Any help from the concept of allostatic load?
Socioeconomic status, hostility, and risk factor clustering in the normative aging study: Any help from the concept of allostatic load?
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DOI：
10.1007/bf02895966
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发表时间：
1999-09-01
影响因子：
3.8
通讯作者：
Sparrow, D
中科院分区：
文献类型：
--
作者：
Kubzansky, LD;Kawachi, I;Sparrow, D
目的：探讨社会经济地位（SES）、心理社会脆弱性（敌意）与非稳态负荷的关系。Allostatic load是指适应stress.Method的累积生理成本：我们研究了SES（以教育程度为衡量标准）之间的关系，敌意和allostatic load在规范的老龄化研究，一项纵向研究，社区居住的男性年龄在21至80岁，在20世纪60年代进入已知的慢性疾病。1986年，修订的明尼苏达多相人格问卷通过邮件进行管理，其中敌意测量是通过将三个Cook-Medley分量表的得分相加得出的：敌意情感，敌意归因，攻击性反应。从1987年至1990年进行的体检期间收集的数据（即反映心血管内分泌和代谢系统的“磨损”的措施），非稳态负荷的指数受到限制。研究了818名男性受教育程度、敌意和非稳态负荷之间的横断面关系。独立的线性回归分析表明，较低的教育程度和较大的敌意都与较高的非稳态负荷得分相关（分别为p <0.05和p < 0.1）。受教育程度较低也与较高的敌意有关（p <0.001）。当非稳态负荷同时回归教育和敌意，教育的影响减弱，而敌意（p <0.05）保持独立的effect.Conclusions：我们的研究结果表明，较低水平的教育和更大的敌意与更大的“磨损”的身体。教育对非稳态负荷的影响可能是由敌意介导的。
Objective: To examine the relationships between socioeconomic status (SES), psychosocial vulnerability (hostility), and allostatic load. Allostatic load refers to the cumulative physiological cost of adaptation to stress.Method: We examined the relationships between SES (as measured by educational attainment), hostility and allostatic load in the Normative Aging Study, a longitudinal study of community-dwelling men aged 21 to 80 years and free of known chronic medical conditions at entry in the 1960s. In 1986, the revised Minnesota Multiphasic Personality Inventory was administered by mail, from which a hostility measure was derived by summing the scores from three Cook-Medley subscales: Hostile Affect, Hostile Attribution Aggressive Responding. An index of allostatic load was constricted from data collected during physical exams conducted between 1987 and 1990 (i.e. measures reflecting "wear and tear" on the cardiovascular endocrine, and metabolic systems). Cross-sectional relationships between education, hostility and allostatic load were examined in 818 men.Results. Separate linear regression analyses indicated that lower levels of educational attainment and greater hostility were both associated with higher allostatic load scores (p < .05 and p < 0.1, respectively). Less education was also associated,vith higher hostility (p < .001). When allostatic load was regressed simultaneously on education and hostility, the effect of education was attenuated, while hostility (p < .05) maintained an independent effect.Conclusions: Our findings suggest that lower levels of education and greater hostility are associated with greater "wear and tear" on the body. The effects of education on allostatic load may be mediated by hostility.