Timing dysfunction and cerebellar resting state functional connectivity abnormalities in youth at clinical high-risk for psychosis.
Timing dysfunction and cerebellar resting state functional connectivity abnormalities in youth at clinical high-risk for psychosis.
复制标题
临床精神病高危青年的时序障碍和小脑静息状态功能连通性异常。
DOI：
10.1017/s0033291719004161
复制
发表时间：
2021-06
影响因子：
6.9
通讯作者：
Mittal, Vijay A.
中科院分区：
文献类型：
--
作者：
Osborne, K. Juston;Damme, Katherine S. F.;Gupta, Tina;Dean, Derek J.;Bernard, Jessica A.;Mittal, Vijay A.
与精神病的病理生理学模型一致，精神分裂症谱系人群中的时间紊乱可能反映了异常的皮质（例如，前额皮质）和皮质下（例如，纹状体）小脑连接。然而，很少有研究探讨小脑连接和定时功能障碍之间的关联在精神病人群中，并没有在青年在临床高风险（ESTA）的精神病。因此，目前尚不清楚颞叶过程的损伤是否存在于青春期，或者它们如何与小脑连接和症状恶化相关。共108名（56名/52名对照）青少年进行了听觉颞叶平分任务沿着与静息状态成像扫描，以检查小脑静息状态连接。还量化了基线和12个月后的阳性和阴性症状。控制酒精和大麻的使用，青少年表现出较差的时间准确性相比，对照组，和时间准确性赤字与异常连接之间的双边前小脑和右侧尾状核/纹状体簇。时间准确性差解释了12个月内阴性症状恶化方差的11%。行为研究结果表明，青少年感知听觉音调的持续时间缩短相比，客观的时间，这可能表明一个较慢的内部时钟。青少年的后颞叶准确性与涉及重要小脑网络的脑区异常相关，该网络与精神病的重要病理生理模型有关。最后，时间准确性与12个月内阴性症状的恶化相关，表明时间功能障碍可能对疾病进展敏感。
Consistent with pathophysiological models of psychosis, temporal disturbances in schizophrenia spectrum populations may reflect abnormal cortical (e.g., prefrontal cortex) and subcortical (e.g., striatum) cerebellar connectivity. However, few studies have examined associations between cerebellar connectivity and timing dysfunction in psychosis populations, and none have been conducted in youth at clinical high-risk (CHR) for psychosis. Thus, it is currently unknown if impairments in temporal processes are present in CHR youth or how they may be associated with cerebellar connectivity and worsening of symptoms. A total of 108 (56 CHR/52 controls) youth were administered an auditory temporal bisection task along with a resting state imaging scan to examine cerebellar resting state connectivity. Positive and negative symptoms at baseline and 12 months later were also quantified. Controlling for alcohol and cannabis use, CHR youth exhibited poorer temporal accuracy compared to controls, and temporal accuracy deficits were associated with abnormal connectivity between the bilateral anterior cerebellum and a right caudate/nucleus accumbens striatal cluster. Poor temporal accuracy accounted for 11% of the variance in worsening of negative symptoms over twelve months. Behavioral findings suggest CHR youth perceive durations of auditory tones as shortened compared to objective time, which may indicate a slower internal clock. Poorer temporal accuracy in CHR youth was associated with abnormalities in brain regions involved in an important cerebellar network implicated in prominent pathophysiological models of psychosis. Lastly, temporal accuracy was associated with worsening of negative symptoms across 12 months, suggesting temporal dysfunction may be sensitive to illness progression.