Necrotic extrafusal muscle fibers of the dystrophic mutant mouse: the ultrastructure of the myoneural junction.
Necrotic extrafusal muscle fibers of the dystrophic mutant mouse: the ultrastructure of the myoneural junction.
复制标题
营养不良突变小鼠的坏死梭外肌纤维：肌神经连接的超微结构。
DOI：
10.1002/ar.1091970404
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Haller,E
中科院分区：
文献类型：
--
作者：
Ontell,M;Haller,E
在产后28天，dy2J突变小鼠的趾长伸肌含有一群肌纤维，其长度的约90%呈现凝固性坏死。使用电子显微镜，运动终板被发现超过一半的坏死纤维的研究，发生在轻度，中度和严重坏死的地区，这些纤维。轴突终末的超微结构特征不随终板所在纤维段的情况而改变。没有形态学标准可以建立区分坏死纤维的轴突终末和营养不良动物的“健康”纤维。坏死纤维的运动终板的主要形态学变化不涉及轴突末端，但肌纤维本身。这项研究表明，坏死的肌纤维，这是目前在发病的第一个临床症状的小鼠营养不良，神经支配。因此，坏死不是由结构性去神经引起的。此外，对轻度、中度和重度坏死肌纤维区域的运动终板的观察表明，沿着坏死肌纤维长度的区域变化不是与运动终板距离的函数。
At 28 days postpartum, the extensor digitorum longus muscle of thedy2Jmutant mouse contains a population of myofibers which exhibit coagulation necrosis for ˜90% of their length. Using the electron microscope, motor endplates were found on more than half of the necrotic fibers studied, occurring in mildly, moderately, and severely necrotic regions of these fibers. The ultrastructural features of the axonal terminals did not vary with the condition of the fiber segment at which the endplate occurred. No morphological criteria could be established for distinguishing between the axonal terminals of necrotic fibers and those of “healthy” fibers in the dystrophic animal. The principle morphological changes at motor endplates of necrotic fibers involved not the axonal terminal, but the muscle fiber itself.This study demonstrates that the necrotic myofibers, which are present at the onset of the first clinical symptoms of murine dystrophy, are innervated. Therefore, necrosis is not precipitated by structural denervation. Furthermore, observations of motor endplates on mildly, moderately, and severely necroctic regions of the myofibers indicate that regional changes along the necrotic fiber 's length are not a function of distance from the motor endplate.