Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
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DOI：
10.1155/2018/7801202
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发表时间：
2018
影响因子：
--
通讯作者：
Ceafalan LC
中科院分区：
文献类型：
--
作者：
Enciu AM;Radu E;Popescu ID;Hinescu ME;Ceafalan LC
转移需要与细胞-细胞和细胞-基质粘附、免疫监视、生长和存活信号通路的激活以及表观遗传修饰相关的细胞变化。除了肿瘤细胞外，肿瘤间质也与原发性肿瘤以及远处转移部位（形成转移性小生境）有关。肿瘤进展中大多数基质伴侣的共同点是CD 36，这是一种脂肪酸摄取的清道夫受体，可调节细胞与细胞外基质的附着、基质细胞命运（脂肪细胞、内皮细胞）、TGFβ活化和免疫信号传导。CD 36已被反复提出作为各种癌症的预后标志物，大多数是上皮来源的（乳腺癌、前列腺癌、卵巢癌和结肠癌），也用于肝癌和神经胶质瘤。在各种癌症的临床前模型中收集的数据表明，阻断CD 36可能有助于阻止转移扩散。然而，在临床试验中用血小板反应蛋白模拟肽靶向受体已被证明是无效的，并且单克隆抗体尚未可用于患者使用。本综述提供了支持CD 36作为癌症潜在预后生物标志物的数据，其目前的阶段是实现真正的生物标志物状态，以及在进一步推进临床实践之前必须填补的知识空白。
Metastasis requires cellular changes related to cell-to-cell and cell-to-matrix adhesion, immune surveillance, activation of growth and survival signalling pathways, and epigenetic modifications. In addition to tumour cells, tumour stroma is also modified in relationship to the primary tumour as well as to distant metastatic sites (forming a metastatic niche). A common denominator of most stromal partners in tumour progression is CD36, a scavenger receptor for fatty acid uptake that modulates cell-to-extracellular matrix attachment, stromal cell fate (for adipocytes, endothelial cells), TGFβ activation, and immune signalling. CD36 has been repeatedly proposed as a prognostic marker in various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas. Data gathered in preclinical models of various cancers have shown that blocking CD36 might prove beneficial in stopping metastasis spread. However, targeting the receptor in clinical trials with thrombospondin mimetic peptides has proven ineffective, and monoclonal antibodies are not yet available for patient use. This review presents data to support CD36 as a potential prognostic biomarker in cancer, its current stage towards achieving bona fide biomarker status, and knowledge gaps that must be filled before further advancement towards clinical practice.
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DOI：
10.1152/ajpendo.00312.2005
发表时间：
2006-03-01
影响因子：
5.1
作者：
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影响因子：
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影响因子：
28.2
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