fMRI adaptation revisited.
fMRI adaptation revisited.
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DOI：
10.1016/j.cortex.2015.10.026
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Kohn A
中科院分区：
文献类型：
--
作者：
Larsson J;Solomon SG;Kohn A
在功能磁共振成像（fMRI）研究中，适应被广泛用于推断人类大脑皮层神经元的反应特性。由于fMRI适应效应和可能构成其基础的多种神经元效应之间的复杂关系，fMRI适应一直受到批评。在过去的十年里，许多关于功能磁共振成像适应性的长期关注得到了神经生理学研究的实证支持。我们在这里回顾这些研究，并考虑神经影像学研究，研究功能磁共振成像适应效应是如何影响高层次的知觉过程。这些研究的结果进一步强调了谨慎解释fMRI适应结果的必要性，但它们也为更准确的解释和更好的实验设计提供了有益的指导。此外，我们认为，而不是被用来作为一个代理的神经刺激选择性的测量，功能磁共振成像适应可能是最有用的研究人群水平的适应效应，在整个皮层处理层次。
Adaptation has been widely used in functional magnetic imaging (fMRI) studies to infer neuronal response properties in human cortex. fMRI adaptation has been criticised because of the complex relationship between fMRI adaptation effects and the multiple neuronal effects that could underlie them. Many of the longstanding concerns about fMRI adaptation have received empirical support from neurophysiological studies over the last decade. We review these studies here, and also consider neuroimaging studies that have investigated how fMRI adaptation effects are influenced by high-level perceptual processes. The results of these studies further emphasize the need to interpret fMRI adaptation results with caution, but they also provide helpful guidance for more accurate interpretation and better experimental design. In addition, we argue that rather than being used as a proxy for measurements of neuronal stimulus selectivity, fMRI adaptation may be most useful for studying population-level adaptation effects across cortical processing hierarchies.