THE ANTIVIRAL SPECTRUM OF LISTERINE ANTISEPTIC
THE ANTIVIRAL SPECTRUM OF LISTERINE ANTISEPTIC
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DOI：
10.1016/s1079-2104(05)80124-6
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发表时间：
1995-04-01
影响因子：
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通讯作者：
CAFFESSE, RG
中科院分区：
文献类型：
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作者：
DENNISON, DK;MEREDITH, GM;CAFFESSE, RG
李施德林防腐剂的抗病毒作用机理和抗病毒谱尚未完全阐明。因此，我们测试了其对1型和2型单纯疱疹病毒（包膜DNA病毒）、甲型流感病毒（包膜RNA病毒）、轮状病毒（无包膜RNA病毒）和5型腺病毒（无包膜DNA病毒）的实验室菌株的作用。将每种病毒与等体积的李施德林混合30秒至5分钟，并评估病毒的残留感染性。抗病毒作用定义为感染性降低95%以上。暴露于李施德林30秒对1型和2型单纯疱疹病毒（感染性病毒分别减少96.3%和100%）和甲型流感病毒（减少100%）具有抗病毒作用。相比之下，轮状病毒诱导的空斑形成减少了12.2%后，暴露于李施德林30秒，而暴露于李施德林5分钟导致21.5%的空斑形成增加。将腺病毒暴露于李施德林对病毒的细胞病变性具有最小的影响，5分钟后病毒水平降低33.4%。因此，李施德林的抗病毒活性与病毒基因组无关，但可能与病毒包膜有关。
The mechanism of activity and the antiviral spectrum of Listerine antiseptic have not been examined thoroughly. We therefore tested its effect on laboratory strains of herpes simplex type 1 and type 2 (enveloped DNA viruses), influenza A virus (enveloped RNA virus), rotavirus (nonenveloped RNA virus), and adenovirus type 5 (nonenveloped DNA virus). Each virus was mixed with an equal Volume of Listerine for 30 seconds to 5 minutes, and the residual infectivity of the virus was assessed. An antiviral effect was defined as greater than 95% reduction of infectivity. Exposure to Listerine for 30 seconds had an antiviral effect against herpes simplex type-1 and type-2 (96.3% and 100% reduction in infectious virus, respectively) and influenza A (100% reduction). In contrast, rotavirus-induced plaque formation was reduced by 12.2% after 30 seconds of exposure to Listerine, whereas 5 minutes of exposure to Listerine resulted in a 21.5% increase in plaque formation. Exposure of adenovirus to Listerine had a minimal effect on the cytopathocity of the virus, with a 33.4% reduction in virus levels after 5 minutes. The antiviral activity of Listerine is thus not related to the viral genome but is probably directed to the viral envelope.