How close are we to complete annotation of metabolomes?
How close are we to complete annotation of metabolomes?
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DOI：
10.1016/j.cbpa.2017.01.001
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发表时间：
2017-02
影响因子：
7.8
通讯作者：
Dunn WB
中科院分区：
文献类型：
--
作者：
Viant MR;Kurland IJ;Jones MR;Dunn WB
代谢组描述了生物系统中存在的数万到数十万种低分子量代谢物的完整补充。代谢组的鉴定对于从代谢组学数据集中发现最大量的生化知识至关重要。然而，迄今为止，尚未报道任何生物体代谢组的详尽实验特征，这与数千种植物、动物和微生物的基因组测序形成鲜明对比。在这里，我们回顾了代谢组注释的现状，并描述了所应用的分析方法的进展。在一定程度上通过新的国际协调，我们得出的结论是，我们现在正在进入代谢组注释的新时代。
The metabolome describes the full complement of the tens to hundreds of thousands of low molecular weight metabolites present within a biological system. Identification of the metabolome is critical for discovering the maximum amount of biochemical knowledge from metabolomics datasets. Yet no exhaustive experimental characterisation of any organismal metabolome has been reported to date, dramatically contrasting with the genome sequencing of thousands of plants, animals and microbes. Here we review the status of metabolome annotation and describe advances in the analytical methodologies being applied. In part through new international coordination, we conclude that we are now entering a new era of metabolome annotation.