ABNORMAL SENSITIVITY TO INTRAVESICAL POTASSIUM IN INTERSTITIAL CYSTITIS AND RADIATION CYSTITIS
ABNORMAL SENSITIVITY TO INTRAVESICAL POTASSIUM IN INTERSTITIAL CYSTITIS AND RADIATION CYSTITIS
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DOI：
10.1002/nau.1930130503
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发表时间：
1994-01-01
影响因子：
2
通讯作者：
LEBOW, D
中科院分区：
文献类型：
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作者：
PARSONS, CL;STEIN, PC;LEBOW, D
尿频尿急综合征 (UFS)（非细菌性膀胱炎、间质性膀胱炎）很可能代表具有多种病因的异质性群体。这项研究基于这样的假设：一部分 UFS 患者具有渗漏（溶质）上皮，因此钾等阳离子可能会在上皮下扩散并引发症状。还假设正常的不可渗透的移行上皮在 K+ 激发试验期间不允许阳离子扩散到细胞中，并且不会出现任何症状。如果上皮是可渗透的（“渗漏的”），就会发生扩散并引发症状。将水或 0.4 M KCl 注入正常志愿者和间质性膀胱炎 (IC) 患者的膀胱内。水不会在两组中引起症状，但 KCl 会引起 4.5% 的正常人和 70% 的 IC 患者出现症状。差异显着（P < 0.0001）。该测试为 UFS 提供了有价值的诊断工具，也为将上皮通透性问题与其他患者亚群区分开来提供了有价值的研究工具。第三组由 11 名接受类肝素治疗缓解的 IC 患者组成，也接受了测试，只有 18% 的患者受到 KCl 的刺激。还对四名放射性膀胱炎患者进行了检查，所有四名患者（100%）都是由钾引起的。 (C) 1994 年 Wiley-Liss 公司
The urgency-frequency syndrome (UFS) (non-bacterial cystitis, interstitial cystitis) may well represent a heterogenous group with several etiologies. This study was based on the hypothesis that one subset of UFS patients has a leaky (to solutes) epithelium and cations such as potassium could thereby diffuse subepithelially and provoke symptoms. It was also hypothesized that normal impermeable transitional epithelium would not allow cations to diffuse across the cells during the K+ provocation test and no symptoms would be experienced. If the epithelium was permeable (''leaky''), diffusion would occur and provoke symptoms. Water or 0.4 M KCl was placed intravesically into normal volunteers and interstitial cystitis (IC) patients. Water did not provoke symptoms in either group but KCl provoked 4.5% of normals and 70% of IC patients. Differences were significant (P < 0.0001). This test provides a valuable diagnostic tool for UFS and a valuable research tool to separate epithelial permeability problems from other subsets of patients. A third group, consisting of 11 IC patients in remission on heparinoid therapy, was also tested and only 18% were provoked by KCl. Four patients with radiation cystitis were also examined and all four (100%) were provoked by the potassium. (C) 1994 Wiley-Liss, Inc.