Molecular mechanisms of T-cell tolerance.
Molecular mechanisms of T-cell tolerance.
复制标题
DOI：
10.1111/j.1600-065x.2011.01012.x
复制
发表时间：
2011-05
影响因子：
8.7
通讯作者：
Dong C
中科院分区：
文献类型：
--
作者：
Nurieva RI;Liu X;Dong C
CD4+ T 细胞是适应性免疫反应的主要调节者，许多自身免疫性疾病是由于 CD4+ T 细胞自身耐受性的崩溃而引起的。 CD4+ T 细胞的激活不仅受到主要肽组织相容性复合物与 T 细胞受体的结合的调节，而且还受到来自抗原呈递细胞的共刺激信号的调节。最近，在理解实现和维持 T 细胞耐受所需的细胞外和细胞内机制方面取得了进展。了解 T 细胞耐受性的分子机制将导致药理学方法的发展，以促进自身免疫的耐受状态或打破癌症的耐受性。
CD4+ T cells are the master regulators of adaptive immune responses, and many autoimmune diseases arise due to a breakdown of self-tolerance in CD4+ T cells. Activation of CD4+ T cells is regulated by not only the binding of peptide-major histocompatibility complexes to T-cell receptor but also costimulatory signals from antigen-presenting cells. Recently, there has been progress in understanding the extracellular and intracellular mechanisms that are required for implementation and maintenance of T-cell tolerance. Understanding of the molecular mechanisms underlying T-cell tolerance will lead to development of pharmacological approaches either to promote the tolerance state in terms of autoimmunity or to break tolerance in cancer.