Autistic traits and cognitive profiles of treatment-resistant schizophrenia
Autistic traits and cognitive profiles of treatment-resistant schizophrenia
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难治性精神分裂症的自闭症特征和认知特征
DOI：
10.1016/j.scog.2020.100186
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发表时间：
2020
影响因子：
--
通讯作者：
Iyo Masaomi
中科院分区：
文献类型：
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作者：
Nakata Yusuke;Kanahara Nobuhisa;Kimura Atsushi;Niitsu Tomihisa;Komatsu Hideki;Oda Yasunori;Ishikawa Masatomo;Hasegawa Tadashi;Kamata Yu;Yamauchi Atsushi;Inazumi Kazuhiko;Kimura Hiroshi;Iyo Masaomi
难治性精神分裂症(TRS)的复杂病理生理包括严重的阳性症状，也包括其他症状域。精神分裂症和自闭症谱系障碍(ASD)的重叠心理特征尚未建立。我们将TRS患者(n=30)与缓解期精神分裂症患者(n=28)和ASD患者(n=28)进行比较，重点关注神经发育方面以及一般和社会认知障碍。TRS组在一般神经认知(通过Matrics Consensus Cognitive Battery衡量)和社会认知(通过心智和情感表达理论衡量)方面表现最差。RemSZ组在三组中表现最好。在自闭症特征方面，自闭症-谱商/自闭症筛查问卷/普遍发展障碍评定量表的所有测量结果表明：(1)自闭症患者具有最高的自闭症特征(2)TRS患者的得分低于ASD组，但(3)总体趋势将TRS组置于ASD组和RemSZ组之间。这些发现表明，TRS患者和缓解期患者可能具有独特的神经发育和认知特征。此外，TRS患者的社会认知功能障碍和自闭症特征的程度可能与ASD患者接近，这表明TRS和ASD之间存在相似之处。
The complex pathophysiology of treatment-resistant schizophrenia (TRS) includes severe positive symptoms but also other symptom domains. The overlapping psychological profiles of schizophrenia and autistic spectrum disorder (ASD) are not established. We compared TRS patients (n = 30) with schizophrenia patients in remission (RemSZ, n = 28) and ASD patients (n = 28), focusing on both neurodevelopmental aspects and general and social cognitive impairments. The TRS group performed the worst on general neurocognition (measured by the MATRICS Consensus Cognitive Battery) and social cognition (measured by the theory of mind and emotional expression). The RemSZ group performed the best among the three groups. Regarding autistic traits, all measurements by the Autism-Spectrum Quotient/Autism Screening Questionnaire/Pervasive Developmental Disorder Assessment Rating Scale showed that (1) the ASD patients had the highest autistic traits (2) the TRS patients' scores were less severe than the ASD group's, but (3) the overall trends placed the TRS group between the ASD and the RemSZ group. These findings indicate that TRS patients and remitted patients could have distinctive neurodevelopmental and cognitive profiles. Further, the degrees of social cognitive dysfunction and autistic traits in TRS patients could be close to those of ASD patients, suggesting similarities between TRS and ASD.