Relative hydrophilicities of cis and trans formamides
Relative hydrophilicities of cis and trans formamides
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顺式和反式甲酰胺的相对亲水性
DOI：
10.1073/pnas.1911331116
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发表时间：
2019-10-01
影响因子：
11.1
通讯作者：
Yu, Yang
中科院分区：
文献类型：
--
作者：
Li, Yong-Sheng;Escobar, Luis;Yu, Yang
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Secondary formamides are widely encountered in biology and exist as mixtures of both cis and trans isomers. Here, we assess hydrophilicity differences between isomeric formamides through direct competition experiments. Formamides bearing long aliphatic chains were sequestered in a water-soluble molecular container having a hydrophobic cavity with an end open to the aqueous medium. NMR spectroscopic experiments reveal a modest preference (