Endurance training enhances BDNF release from the human brain
Endurance training enhances BDNF release from the human brain
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DOI：
10.1152/ajpregu.00525.2009
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发表时间：
2010-02-01
影响因子：
2.8
通讯作者：
Secher, Niels H.
中科院分区：
文献类型：
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作者：
Seifert, Thomas;Brassard, Patrice;Secher, Niels H.
Seifert T，Brassard P，Wissenberg M，Rasmussen P，Nordby P，Stallkeck B，Adser H，Jakobsen AH，Pilegaard H，Nielsen HB，Secher NH。耐力训练增强了人脑中BDNF的释放。Am J Physiol Regul Integr Comp Physiol 298：R372-R377,2010.2009年11月18日首次出版；doi：10.1152/ajpregu.00525.2009。-严重抑郁症和2型糖尿病患者的脑源性神经营养因子循环水平降低。由于急性运动增加了海马区和大脑皮层中BDNF的产生，我们假设耐力训练会增加从动脉和颈内静脉血样本中检测到的人脑BDNF的释放。在一项随机对照研究中，12名健康久坐的男性进行了3个月的耐力训练(n=7)或作为对照(n=5)。干预前后，分别在安静状态和运动状态下采集血样。在基线时，训练组(58+/-106 ng.100 g(-1).min(-1)，Means+/-SD)和对照组(12+/-17 ng.100 g(-1).min(-1))在静息状态下有相似的脑源性神经营养因子释放。3个月的耐力训练使BDNF的静息释放量增加到206+/-108 ng·100g(-1)·min(-1)(P<；0.05)，对照组无明显变化，但运动中BDNF的释放量未见明显增加。此外，与未接受训练的小鼠相比，8只小鼠完成了5周跑步机训练方案，增加了海马区BDNF mRNA的表达(4.5+/-1.6vs.1.4+/-1.1mRNA/ssDNA；P<；0.05)，但不增加大脑皮层的BDNF mRNA表达(4.0+/-1.4mRNAvs.4.6+/-1.4mRNA/ssDNA)。训练后海马区BDNF表达增加，人脑BDNF释放增加，提示耐力训练促进大脑健康。
Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol 298: R372-R377, 2010. First published November 18, 2009; doi:10.1152/ajpregu.00525.2009.-The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 +/- 106 ng.100 g(-1).min(-1), means +/- SD) and the control group (12 +/- 17 ng.100 g(-1).min(-1)) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 +/- 108 ng.100 g(-1).min(-1) (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 +/- 1.6 vs. 1.4 +/- 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 +/- 1.4 vs. 4.6 +/- 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.