Gap junctional intercellular communication and the regulation of connexin expression and function
Gap junctional intercellular communication and the regulation of connexin expression and function
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DOI：
10.1016/0955-0674(90)90086-t
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发表时间：
1990-10-01
影响因子：
7.5
通讯作者：
Goodenough, D. A.
中科院分区：
文献类型：
--
作者：
Musil, L. S.;Goodenough, D. A.
间隙连接是直接连接相邻细胞的胞浆的跨膜通道的集合（综述于班尼特和Goodenough，Neurosci Res Prog Bull 1978，16：373-486）。在几乎所有动物组织中发现，间隙连接在后生动物中为低分子量物质的细胞-细胞转移问题提供了几乎普遍存在的解决方案，而不暴露于细胞外环境。差距连接通道由嵌入一个细胞质膜中的半通道（连接子）组成，其与并置细胞膜中的连接子镜像对称地连接（由Caspar等人综述，在现代细胞生物学编辑的赫茨伯格和约翰逊。Alan R利斯，1988年，第117-133页）。每个连接子是一个寡聚体的六个完整的膜蛋白亚基，描绘了一个1.5 mn直径的水孔渗透无机离子和小代谢产物。1986年对这些蛋白质之一的分子克隆（Paul，J Cell Biol 1986，103：123-134; Kumar和Gilula，J Cell Biol 1986，103：767-776）导致发现了广泛分布的相关间隙连接蛋白家族，即连接蛋白。连接蛋白的基本结构特征去年由史蒂文森和保罗在该杂志中综述（Cum Opin Cell Biol 989，1991），最近由拜尔（Beyer）等人综述。（《生物学》990，116：187-194）。在这篇综述中，将讨论连接蛋白家族的三个成员的调节：连接蛋白32（Paul，1986; Kumar和Gilula 1986）、连接蛋白26（Zhang和Nicholson，J Cell Biol 1989，109：3391-3401）和连接蛋白43（Beyer等，J Cell Biol 987，105：2621-2629）。
Gap junctions are collections of transmembrane channels which directly link the cytoplasms of adjoining cells (reviewed in Bennett and Goodenough, Neurosci Res Prog Bull 1978, 16: 373-486). Found in virtually all animal tissues, gap junctions provide an almost ubiquitous solution in metazoans to the problem of cell-to-cell transfer of low-molecular-weight substances without exposure to the extracellular environment.The gap junction channel is composed of a hemichannel (connexon) embedded in the plasma membrane of one ceU joined in mirror symmetry with a connexon in the apposing ceU membrane (reviewed by Caspar et al., In Modem Cell Biology edited by Hertzberg and Johnson. Alan R Liss, 1988, pp 117-133). Each connexon is an oligomer of six integral membrane protein subunits which delineate a 1.5 mn diameter aqueous pore permeable to inorganic ions and small metabolites. The molecular cloning of one of these proteins in 1986 (Paul, J Cell Biol 1986, 103: 123-134; Kumar and Gilula, J Cell Biol 1986, 103: 767-776) has led to the discovery of a widely distributed family of related gap junction proteins, the connexins. The basic structural features of connexins were reviewed in this journal last year by Stevenson and Paul (Cum Opin Cell Bioll989, l&%-891> and more recently by Beyer et al.(I Membr Bioll990, 116: 187-194). In this review, the regulation of three members of the connexin family will be discussed: connexin32 (Paul, 1986; Kumar and Gilula 1986), connexin26 (Zhang and Nicholson, J Cell Biol 1989, 109: 3391-3401), and connexin43 (Beyer et al, J Cell Bioll987, 105: 2621-2629).