Potential Sources of Bisphenol A in the Neonatal Intensive Care Unit
Potential Sources of Bisphenol A in the Neonatal Intensive Care Unit
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DOI：
10.1542/peds.2012-1380
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发表时间：
2013-03-01
期刊：
影响因子：
8
通讯作者：
Ringer, Steven
中科院分区：
文献类型：
--
作者：
Duty, Susan M.;Mendonca, Kaitlin;Ringer, Steven
目的：为了确定是否营养摄入和医疗器械的双酚A（BPA）暴露源早产儿在新生儿重症监护室。方法：母亲和他们的早产儿照顾在新生儿重症监护室在过去的3天招募本暴露评估研究。43名母亲提供了1份营养样本（母乳或配方奶粉），以描述婴儿的摄入量。从55名婴儿中的每一个收集两份尿液样本（喂养前和喂养后）。根据所用器械的数量和侵入性，将医疗器械使用分为“低”或“高”。采用在线固相萃取、高效液相色谱、同位素稀释、串联质谱等方法测定尿中BPA浓度，并以此作为估算BPA暴露量的生物标志物。非参数等效性检验，组内相关性，分层线性混合效应models carried.RESULTS：母乳和配方奶粉样本没有不同的总BPA浓度，也没有婴儿的总BPA的尿中浓度的中位数之前或之后喂养。然而，在过去3天内需要使用4个或更多医疗器械的婴儿的尿中总BPA浓度中位数（36.6 μ g/L）显著高于需要使用0至3个器械的婴儿（13.9 μ g/L）。计算出的BPA暴露量低于美国环境保护署的参考剂量，但相当高（16- 32倍）比婴儿或儿童从一般population.CONCLUSIONS：在过去3天内使用的医疗器械的数量，但不是营养摄入量，与BPA暴露呈正相关。儿科2013;131：483-489
OBJECTIVES: To determine whether nutritional intake and medical devices are bisphenol A (BPA) exposure sources among premature infants in the NICU.METHODS: Mothers and their premature infants cared for in the NICU for the past 3 days were recruited for this exposure assessment study. Forty-three mothers contributed 1 nutrition sample (breast milk or formula) to characterize the infant's intake. Two urine samples (before and after feeding) were collected from each of 55 infants. Medical device use was categorized as "low" or "high" based on the number and invasiveness of devices used. BPA urinary concentrations used as a biomarker to estimate BPA exposure were measured by online solid-phase extraction, high performance liquid chromatography, isotope dilution, tandem mass spectrometry. Nonparametric equivalence tests, intraclass correlations, and hierarchical linear mixed-effects models were conducted.RESULTS: Breast milk and formula samples did not differ in total BPA concentration nor did infants' median urinary concentration of total BPA before or after feedings. However, the median urinary total BPA concentration among infants who required the use of 4 or more medical devices in the past 3 days was significantly higher (36.6 mu g/L) than among infants who required the use of 0 to 3 devices (13.9 mu g/L). The calculated BPA exposures are lower than the US Environmental Protection Agency reference dose, but considerably higher (16- to 32-fold) than among infants or children from the general population.CONCLUSIONS: The number of medical devices used in the past 3 days, but not nutritional intake, was positively associated with exposure to BPA. Pediatrics 2013;131:483-489