Synthesis and Characterization of Silicone Contact Lenses Based on TRIS-DMA-NVP-HEMA Hydrogels
Synthesis and Characterization of Silicone Contact Lenses Based on TRIS-DMA-NVP-HEMA Hydrogels
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DOI：
10.3390/polym11060944
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发表时间：
2019-06-01
期刊：
影响因子：
5
通讯作者：
Ming-Chien Yang
中科院分区：
文献类型：
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作者：
Nguyen-Phuong-Dung Tran;Ming-Chien Yang
本研究采用3-（甲基丙烯酰氧基）丙基（三甲基硅氧基）硅烷（TRIS）、N，N-二甲基丙烯酰胺（DMA）、1-乙烯基-2-吡罗烷酮（NVP）和2-羟甲基丙烯酸乙酯（HEMA）聚合法制备了硅基水凝胶隐形眼镜。通过平衡含水量、透氧性、光学透明度、接触角、力学测试、蛋白质吸附和细胞毒性等方法分析了硅酮水凝胶透镜的性能。结果表明，各配方中TRIS含量均增加了水凝胶的透氧性，降低了平衡含水量，而DMA和NVP均对水凝胶的亲水性有贡献。氧渗透率最大值为74.9个阻隔，对应的平衡含水量为44.5%，接触角为82度。此外，L929成纤维细胞在所有这些水凝胶上生长，表明无细胞毒性。总的来说，本研究中的硅酮水凝胶具有良好的透氧性、刚度、光学透明性和抗蛋白质吸附性。因此，这些硅水凝胶聚合物可以用于制造隐形眼镜。
In this study, silicone-based hydrogel contact lenses were prepared by the polymerization of 3-(methacryloyloxy)propyltris(trimethylsiloxy)silane (TRIS), N,N-dimethylacrylamide (DMA), 1-vinyl-2-pyrrolidinone (NVP), and 2-hydroxyethylmethacrylate (HEMA). The properties of silicone hydrogel lenses were analyzed based on the methods such as equilibrium water content, oxygen permeability, optical transparency, contact angle, mechanical test, protein adsorption, and cell toxicity. The results showed that the TRIS content in all formulations increased the oxygen permeability and decreased the equilibrium water content, while both DMA and NVP contributed the hydrophilicity of the hydrogels. The maximum value of oxygen permeability was 74.9 barrers, corresponding to an equilibrium water content of 44.5% as well as a contact angle of 82 degrees. Moreover, L929 fibroblasts grew on all these hydrogels, suggesting non-cytotoxicity. In general, the silicone hydrogels in this work exhibited good oxygen permeability, stiffness, and optical transparency as well as anti-protein adsorption. Hence, these silicone hydrogel polymers would be feasible for making contact lens.