Death receptors couple to both cell proliferation and apoptosis.
Death receptors couple to both cell proliferation and apoptosis.
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DOI：
10.1172/jci15077
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发表时间：
2002-02
期刊：
影响因子：
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通讯作者：
R. Budd
中科院分区：
文献类型：
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作者：
R. Budd
没有人会质疑死亡受体的作用正如它的名字所暗示的那样，诱导程序性细胞死亡。此外，最近的一些报道表明，这些受体或其下游调节因子也可能在细胞生长或分化的某些方面起作用。这些说法可能会受到合理的怀疑。当然，在细胞的命运中，没有什么比生长和死亡更相反的了。然而，这两个过程所使用的信号通路似乎是混合的，并且信号矢量的最终结果可能由于这些成分之间看似微妙的平衡而倾向于一种结果而不是另一种结果。在这里，简要回顾了从死亡受体激活到细胞凋亡的传统信号通路后，我仔细审查了由这些受体介导的生长或分化增加的各种报告。然后，我考虑新发现的与死亡受体相关的信号通路，这些信号通路可能促进生长，最后，推测这些事件是否仅仅代表了有趣的体外操作或实际的生理重要过程。
No one will dispute that death receptors do exactly what their name suggests, induce programmed cell death. In addition, however, several reports have recently suggested that these receptors, or their downstream regulators, may also function in certain aspects of cell growth or differentiation. These claims might be met with justifiable skepticism. Certainly there is nothing more opposite in cell fate than growth and death. Yet the signal pathways used by these two processes appear to commingle, and the eventual outcome of the signaling vector may be bent toward one result over the other by seemingly subtle balances among these components. Here, following a brief review of the traditional signal pathways that lead from death receptor activation to apoptosis, I scrutinize the various reports of increased growth or differentiation mediated by these same receptors. I then consider newly identified signal pathways linked to death receptors that might promote growth and, finally, speculate on whether these events represent merely interesting in vitro manipulations or actual physiologically important processes.