Organotypic slice cultures from transgenic mice as disease model systems
Organotypic slice cultures from transgenic mice as disease model systems
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DOI：
10.1385/jmn:19:3:317
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发表时间：
2002-12-01
影响因子：
3.1
通讯作者：
Matsuoka, Y
中科院分区：
文献类型：
--
作者：
Duff, K;Noble, W;Matsuoka, Y
Organotypic slice cultures have been prepared from the brains of transgenic mice with Alzheimer's disease-type pathology. Cell types within the slice undergo differentiation and slices can be maintained in culture for up to 6 mo when prepared from young neonates. Slices have been prepared from mice overexpressing genes of relevance to Alzheimer's disease, including mutant or wild-type tau. Neurons in these slices develop neurons that are immunoreactive for a number of markers of abnormal tau. Organotypic slice models are currently being used to test the impact of tangle enhancers or inhibitors as a prescreen for efficacy before testing drugs in vivo.
