Is the functional connectivity within temporal lobe influenced by saccadic eye movements?
Is the functional connectivity within temporal lobe influenced by saccadic eye movements?
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DOI：
10.1152/jn.2002.88.4.1675
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发表时间：
2002-10
影响因子：
2.5
通讯作者：
S. Sobotka;Wei Zuo;J. Ringo
中科院分区：
文献类型：
--
作者：
S. Sobotka;Wei Zuo;J. Ringo
局部诱发电位（LEPs），记录在响应电刺激，被用来研究颞叶不同部位之间的功能连接。永久性电极植入颞下皮层（IT）和海马结构（HF）的前部和后部。在每个实验阶段，刺激这四个部位中的一个，并在其他部位记录LEPs。在前部和后部IT部位对前部和后部HF的刺激做出反应，发现了清晰的LEP。双向连接（根据电位判断）被发现之间的前部和后部网站相同的结构（IT或HF）。LEPs的时间表明，大部分反应是在多突触回路中进行的。刺激后，猴子进行了扫视产生较大的晚期成分的LEPs比相同的刺激没有扫视。的影响是最大的扫视和电刺激之间的延迟结束时，在50-100毫秒的范围内。这种扫视调制的功能连接内IT（双向）和后HF和IT（单向）之间观察。
Local evoked potentials (LEPs), recorded in response to electrical stimulation, were used to study functional connectivity between different sites of the temporal lobe. Permanent electrodes were implanted in anterior and posterior positions of both inferotemporal cortex (IT) and hippocampal formation (HF). In each experimental session, one of these four sites was stimulated and LEPs were recorded in the others. Clear LEPs were found in the anterior and posterior IT sites in response to stimulation of the anterior as well as posterior HF. Bidirectional connections (as judged by the potentials) were found between the anterior and posterior sites of the same structure (IT or HF). The timing of the LEPs indicates that much of the response was carried in multisynaptic circuits. Stimulation delivered just after the monkey made a saccade produced larger late components in the LEPs than the same stimulation delivered without a saccade. The influence was maximal when the delay between the end of the saccade and the electrical stimulation was in the range of 50-100 ms. This saccadic modulation of the functional connectivity was observed within IT (bidirectional) and between posterior HF and IT (unidirectional).