Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.
Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.
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DOI：
10.1002/alz.12405
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Pase MP
中科院分区：
文献类型：
--
作者：
Baril AA;Beiser AS;Sanchez E;Mysliwiec V;Redline S;Gottlieb DJ;O'Connor GT;Gonzales MM;Himali D;Seshadri S;Himali JJ;Pase MP
我们评估了失眠症状的严重程度是否与认知功能相关，以及这种关系是否被与阿尔茨海默病风险相关的生物标志物所改变。我们在3.4年后检查了511名无痴呆的心脏病研究参与者（62.65 ± 8.7岁，50.9%男性）的失眠症状和神经心理学表现。此外，我们探讨了失眠症状与自我报告的习惯性睡眠时间短和载脂蛋白E（APOE）ε4等位基因状态的影响。更严重的失眠症状与整体认知、即时和延迟逻辑记忆回忆的表现较低相关，特别是当失眠症状与睡眠时间短相结合时。失眠症状与记忆力下降之间的关联在APOE ε4等位基因携带者中更为明显。失眠症状的严重程度与随后的整体认知和记忆表现较差相关，这在APOE ε4等位基因携带者中尤其明显，这表明当大脑已经容易受到神经退行性变的影响时，睡眠不足可能特别有害。
We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer’s disease risk. We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status. More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers. Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.
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